HNF1A Gene Maturity-Onset Diabetes of the Young Type 3 NGS Genetic DNA Test
Understanding MODY Type 3 Genetic Testing
The HNF1A Gene Maturity-Onset Diabetes of the Young Type 3 NGS Genetic DNA Test represents a breakthrough in personalized diabetes care. This advanced diagnostic tool specifically targets mutations in the HNF1A (Hepatocyte Nuclear Factor 1 Alpha) gene, which plays a critical role in pancreatic beta cell function and insulin production. MODY Type 3 is an autosomal dominant form of diabetes that typically manifests in adolescence or early adulthood, distinguishing it from both Type 1 and Type 2 diabetes.
What This Test Measures and Detects
Our comprehensive NGS (Next-Generation Sequencing) genetic analysis examines the entire coding region of the HNF1A gene to identify:
- Point mutations affecting gene function
- Small insertions and deletions
- Missense, nonsense, and frameshift mutations
- Splice site variations
- Regulatory region abnormalities
The test specifically detects genetic variations that impair the HNF1A protein’s ability to regulate insulin gene expression and maintain normal glucose homeostasis. These mutations lead to progressive beta cell dysfunction, resulting in the characteristic clinical features of MODY Type 3.
Who Should Consider HNF1A Genetic Testing?
This test is particularly recommended for individuals presenting with:
- Diabetes diagnosed before age 25
- Strong family history of diabetes across multiple generations
- Atypical diabetes presentation not fitting Type 1 or Type 2 patterns
- Mild fasting hyperglycemia with significant postprandial glucose elevations
- Excellent response to sulfonylurea medications
- Absence of pancreatic autoantibodies
- Non-obese individuals with diabetes
- Renal glycosuria without hyperglycemia
Clinical Benefits of HNF1A Genetic Testing
Understanding your HNF1A genetic status provides numerous clinical advantages:
- Personalized Treatment Planning: MODY Type 3 patients often respond exceptionally well to low-dose sulfonylureas, potentially avoiding insulin therapy
- Accurate Diagnosis: Distinguishes MODY from other diabetes types, guiding appropriate management strategies
- Family Risk Assessment: Identifies at-risk family members for early intervention and monitoring
- Prognostic Information: Provides insight into disease progression and potential complications
- Reproductive Planning: Offers genetic counseling opportunities for family planning decisions
Understanding Your Test Results
Your HNF1A genetic test results will fall into one of several categories:
Positive Result
A positive result indicates the presence of a pathogenic mutation in the HNF1A gene, confirming MODY Type 3 diagnosis. This finding typically leads to:
- Transition to sulfonylurea therapy when appropriate
- Discontinuation of insulin if previously prescribed
- Family screening recommendations
- Long-term monitoring plan development
Negative Result
A negative result suggests that HNF1A mutations are not responsible for the diabetes presentation. This outcome helps:
- Rule out MODY Type 3 specifically
- Guide investigation toward other diabetes subtypes
- Focus on alternative diagnostic possibilities
- Prevent unnecessary medication changes
Variant of Uncertain Significance (VUS)
Occasionally, genetic variants of unknown clinical significance may be identified. In such cases:
- Additional family studies may be recommended
- Clinical correlation with diabetes presentation is essential
- Periodic re-evaluation as genetic knowledge advances
- Conservative management until significance is determined
Test Information and Pricing
| Test Component | Details |
|---|---|
| Test Name | HNF1A Gene Maturity-Onset Diabetes of the Young Type 3 NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) |
Pre-Test Requirements
Before undergoing HNF1A genetic testing, we recommend:
- Comprehensive clinical history documentation
- Genetic counseling session with our certified genetic counselors
- Development of detailed family pedigree chart
- Discussion of potential outcomes and implications
- Informed consent process completion
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified collection centers ensures accessible genetic testing services nationwide.
Take Control of Your Diabetes Diagnosis Today
Don’t let uncertainty about your diabetes diagnosis prevent you from receiving the most appropriate care. The HNF1A genetic test provides definitive answers that can transform your treatment approach and improve long-term health outcomes. Our team of genetic specialists and diabetes experts are ready to guide you through this important diagnostic journey.
Call us now at +1(267) 388-9828 to schedule your genetic counseling session and HNF1A testing appointment. Take the first step toward personalized diabetes management and discover if MODY Type 3 is the underlying cause of your condition.
