ITGB1 Gene Leukocyte Adhesion Deficiency NGS Genetic DNA Test
Comprehensive Genetic Analysis for Immune System Disorders
The ITGB1 Gene Leukocyte Adhesion Deficiency NGS Genetic DNA Test represents a cutting-edge diagnostic tool in the field of immunogenetics. This specialized test utilizes next-generation sequencing technology to analyze the ITGB1 gene, which plays a critical role in the proper functioning of the immune system. Leukocyte Adhesion Deficiency Type 1 (LAD-1) is a rare autosomal recessive disorder characterized by defects in leukocyte adhesion and migration, leading to severe recurrent infections and impaired inflammatory responses.
What Does This Test Measure and Detect?
This comprehensive genetic test specifically targets the ITGB1 gene, which encodes the CD18 subunit of β2 integrins. These integrins are essential for leukocyte adhesion to endothelial cells and subsequent migration to sites of infection. The test detects:
- Point mutations in the ITGB1 gene coding regions
- Small insertions and deletions affecting gene function
- Copy number variations that may impact gene expression
- Splice site mutations affecting mRNA processing
- Novel genetic variants with potential clinical significance
Who Should Consider This Genetic Test?
This test is particularly recommended for individuals presenting with the following clinical symptoms:
- Recurrent bacterial infections without pus formation
- Delayed separation of the umbilical cord beyond 3 weeks
- Poor wound healing and impaired tissue repair
- Severe gingivitis and periodontal disease
- Persistent leukocytosis with elevated neutrophil counts
- Family history of immune deficiency disorders
- Unexplained recurrent skin and soft tissue infections
- Children with failure to thrive and recurrent infections
Key Benefits of ITGB1 Genetic Testing
Undergoing this comprehensive genetic analysis provides numerous clinical advantages:
- Early and Accurate Diagnosis: Enables precise identification of LAD-1 before severe complications develop
- Personalized Treatment Planning: Guides appropriate antimicrobial prophylaxis and management strategies
- Family Genetic Counseling: Provides crucial information for family planning and carrier testing
- Stem Cell Transplant Guidance: Identifies candidates who may benefit from hematopoietic stem cell transplantation
- Prognostic Information: Helps predict disease severity and expected clinical course
- Research Contribution: Advances understanding of rare immune disorders
Understanding Your Test Results
Our comprehensive genetic report provides detailed interpretation of your results:
- Positive Result: Indicates the presence of pathogenic mutations in the ITGB1 gene, confirming LAD-1 diagnosis
- Negative Result: Suggests no disease-causing variants were detected, though clinical correlation is essential
- Variant of Uncertain Significance (VUS): Identifies genetic changes with unknown clinical impact requiring further evaluation
- Carrier Status: Detects individuals with one mutated copy who may pass the condition to offspring
All results are accompanied by detailed clinical correlations and recommendations from our board-certified genetic specialists.
Test Pricing and Details
| Test Component | Details |
|---|---|
| Test Name | ITGB1 Gene Leukocyte Adhesion Deficiency NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements
Before undergoing testing, we recommend:
- Comprehensive clinical history documentation
- Genetic counseling session with our certified genetic counselors
- Development of detailed pedigree chart documenting family history
- Discussion of potential implications and limitations of testing
- Informed consent process explaining benefits and risks
Nationwide Testing Availability
We proudly offer our comprehensive genetic testing services across the United States, with convenient locations in:
- New York City, NY
- Los Angeles, CA
- Chicago, IL
- Houston, TX
- Phoenix, AZ
- Philadelphia, PA
- San Antonio, TX
- San Diego, CA
- Dallas, TX
- San Jose, CA
Our state-of-the-art laboratories ensure consistent, high-quality results regardless of your location.
Take Control of Your Health Today
Don’t let uncertainty about immune system disorders affect your quality of life. Our ITGB1 Gene Leukocyte Adhesion Deficiency NGS Genetic DNA Test provides the clarity you need for informed healthcare decisions. Early diagnosis can significantly improve outcomes and guide appropriate treatment strategies.
Call us now at +1(267) 388-9828 to schedule your genetic counseling session and testing appointment. Our genetic specialists are available to answer your questions and guide you through the testing process.
Alternatively, you can WhatsApp us at the same number for convenient scheduling and preliminary consultations. Take the first step toward understanding your genetic health and ensuring proper management of potential immune system disorders.
