SPG21 Gene NGS Genetic DNA Test

Comprehensive Genetic Testing for Hereditary Spastic Paraplegia

The SPG21 Gene NGS Genetic DNA Test represents a breakthrough in neurological genetic diagnostics, offering precise detection of mutations associated with hereditary spastic paraplegia type 21. This advanced genetic analysis provides crucial insights for individuals and families affected by progressive neurological conditions, enabling early intervention and personalized treatment approaches.

What Does the SPG21 Gene Test Measure?

This sophisticated genetic test specifically targets the SPG21 gene (also known as the ACP33 gene) using next-generation sequencing technology to identify pathogenic variants that cause hereditary spastic paraplegia. The test examines:

• Complete coding regions of the SPG21 gene
• Exon-intron boundaries for splice site mutations
• Copy number variations and structural rearrangements
• Point mutations, insertions, and deletions
• Autosomal recessive inheritance patterns

Who Should Consider SPG21 Genetic Testing?

This test is recommended for individuals experiencing symptoms of hereditary spastic paraplegia or those with family history of neurological disorders:

• Progressive leg stiffness and muscle spasticity
• Difficulty walking or changes in gait pattern
• Muscle weakness in lower extremities
• Family history of spastic paraplegia
• Unexplained neurological symptoms in childhood or adulthood
• Developmental delays with progressive neurological decline
• Individuals with confirmed SPG21 mutations in family members

Clinical Benefits of SPG21 Genetic Testing

Undergoing SPG21 genetic testing provides numerous clinical advantages:

• Accurate Diagnosis: Confirms or rules out hereditary spastic paraplegia type 21
• Early Intervention: Enables proactive management before significant disability develops
• Family Planning: Provides crucial information for genetic counseling and reproductive decisions
• Personalized Treatment: Guides targeted therapeutic approaches and rehabilitation strategies
• Prognostic Information: Helps predict disease progression and potential complications
• Research Contribution: Advances understanding of rare neurological disorders

Understanding Your Test Results

Our comprehensive genetic counseling service helps you interpret your SPG21 test results:

• Positive Result: Indicates presence of pathogenic SPG21 mutations; confirms hereditary spastic paraplegia diagnosis
• Negative Result: No detected mutations; reduces likelihood of SPG21-related disorder
• Variant of Uncertain Significance: Identifies genetic changes with unknown clinical impact requiring further evaluation
• Carrier Status: Identifies individuals who carry one copy of mutated gene without symptoms

Test Details and Pricing

Nationwide Testing Availability

We have diagnostic centers conveniently located across the United States, including major metropolitan areas such as New York City, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures accessible genetic testing services for patients throughout the country.

Take Control of Your Neurological Health

Don’t let uncertainty about hereditary neurological conditions affect your quality of life. Our SPG21 Gene NGS Genetic DNA Test provides the clarity you need for informed healthcare decisions. With comprehensive genetic counseling included, you’ll receive expert guidance throughout the testing process and result interpretation.

Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic testing appointment or to speak with our genetic counseling team. Early detection through genetic testing can make a significant difference in managing hereditary spastic paraplegia and improving long-term outcomes.