KLF8 Gene Mental Retardation Nonsyndromic NGS Genetic DNA Test
Comprehensive Genetic Testing for Intellectual Disability
The KLF8 Gene Mental Retardation Nonsyndromic NGS Genetic DNA Test represents a significant advancement in neurological genetic diagnostics. This specialized test focuses on identifying mutations in the KLF8 gene, which plays a crucial role in brain development and cognitive function. Nonsyndromic mental retardation refers to intellectual disability that occurs without additional physical abnormalities or systemic health issues, making genetic testing particularly important for accurate diagnosis and management.
What Does This Test Measure and Detect?
This advanced genetic test utilizes Next-Generation Sequencing (NGS) technology to comprehensively analyze the KLF8 gene for:
- Point mutations and single nucleotide variations
- Small insertions and deletions (indels)
- Copy number variations affecting the KLF8 gene
- Regulatory region mutations impacting gene expression
- Pathogenic variants associated with intellectual disability
The KLF8 gene encodes a transcription factor that regulates numerous downstream genes involved in neuronal development, synaptic plasticity, and cognitive processes. Mutations in this gene disrupt normal brain development, leading to nonsyndromic mental retardation characterized by intellectual disability without other physical manifestations.
Who Should Consider This Test?
This genetic test is recommended for individuals exhibiting:
- Unexplained developmental delays in childhood
- Significant learning difficulties and academic challenges
- Intellectual disability without physical abnormalities
- Family history of nonsyndromic mental retardation
- Unexplained cognitive impairment in multiple family members
- Developmental regression or plateau in cognitive skills
- Difficulty with abstract thinking and problem-solving
Clinical Benefits of KLF8 Genetic Testing
Undergoing KLF8 gene testing provides numerous clinical advantages:
- Accurate Diagnosis: Provides definitive genetic confirmation of nonsyndromic mental retardation
- Personalized Interventions: Enables targeted educational and therapeutic approaches
- Family Planning Guidance: Offers crucial information for genetic counseling and reproductive decisions
- Prognostic Information: Helps predict disease progression and potential complications
- Early Intervention: Facilitates timely implementation of support services
- Reduced Diagnostic Odyssey: Minimizes unnecessary medical testing and procedures
Understanding Your Test Results
Your KLF8 genetic test results will fall into one of several categories:
- Positive Result: Indicates the presence of a pathogenic mutation in the KLF8 gene, confirming the genetic basis of intellectual disability
- Negative Result: Suggests no mutation detected in the KLF8 gene, though other genetic causes may still be present
- Variant of Uncertain Significance (VUS): Identifies a genetic change whose clinical significance is currently unknown
- Carrier Status: May identify individuals who carry the mutation but do not exhibit symptoms
All results are accompanied by comprehensive genetic counseling to ensure proper interpretation and appropriate next steps. Our team of genetic specialists will guide you through understanding the implications of your results and developing a personalized management plan.
Test Pricing Information
| Test Component | Price (USD) |
|---|---|
| KLF8 Gene Mental Retardation Nonsyndromic NGS Genetic DNA Test | $700 |
| Discount Price | $500 |
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art facilities ensure consistent, high-quality testing standards nationwide.
Sample Collection and Processing
This test requires one of the following sample types:
- Blood sample collected by trained phlebotomists
- Extracted DNA from previous genetic testing
- One drop of blood on FTA card for convenient collection
Turnaround time for results is typically 3 to 4 weeks from sample receipt. Pre-test requirements include providing complete clinical history and participating in a genetic counseling session to create a detailed family pedigree chart.
Take the Next Step Toward Answers
If you or a family member are experiencing unexplained intellectual disability or developmental challenges, the KLF8 Gene Mental Retardation Nonsyndromic NGS Genetic DNA Test could provide the answers you need. Our team of neurological genetics specialists is ready to help you understand your genetic profile and develop appropriate management strategies.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and testing appointment. Take control of your genetic health journey with comprehensive, accurate testing from America’s leading genetics laboratory.
