GDAP1 Gene CMT4A NGS Genetic DNA Test
Comprehensive Genetic Testing for Charcot-Marie-Tooth Type 4A
The GDAP1 Gene CMT4A NGS Genetic DNA Test represents a breakthrough in neurological genetic diagnostics, offering precise identification of mutations associated with Charcot-Marie-Tooth disease Type 4A. This advanced testing methodology utilizes next-generation sequencing technology to provide comprehensive analysis of the GDAP1 gene, enabling accurate diagnosis and personalized treatment planning for patients with suspected hereditary neuropathies.
What Does the GDAP1 Gene CMT4A Test Measure?
This sophisticated genetic test specifically targets the GDAP1 (Ganglioside-Induced Differentiation-Associated Protein 1) gene, which plays a critical role in mitochondrial function and peripheral nerve health. The test detects:
- Pathogenic variants and mutations in the GDAP1 gene
- Autosomal recessive inheritance patterns characteristic of CMT4A
- Specific genetic alterations responsible for progressive peripheral neuropathy
- Mutation types including missense, nonsense, and frameshift variants
- Complete coding region analysis with comprehensive coverage
Who Should Consider GDAP1 Genetic Testing?
This test is particularly recommended for individuals presenting with symptoms suggestive of Charcot-Marie-Tooth disease Type 4A, including:
- Progressive muscle weakness in feet and hands beginning in childhood
- Foot deformities such as high arches (pes cavus) or hammertoes
- Difficulty walking or frequent tripping
- Reduced sensation in extremities
- Family history of similar neurological symptoms
- Early-onset peripheral neuropathy without clear cause
- Consanguineous parents or affected siblings
Clinical Benefits of GDAP1 Genetic Testing
Undergoing GDAP1 genetic testing provides numerous clinical advantages:
- Definitive Diagnosis: Confirms or rules out CMT4A with high accuracy
- Treatment Guidance: Informs appropriate therapeutic interventions
- Prognostic Information: Helps predict disease progression and severity
- Family Planning: Provides crucial information for genetic counseling
- Early Intervention: Enables proactive management strategies
- Differential Diagnosis: Distinguishes CMT4A from other neuropathy types
Understanding Your Test Results
Your GDAP1 genetic test results will be carefully interpreted by our team of board-certified genetic specialists and neurologists:
- Positive Result: Indicates pathogenic mutations in the GDAP1 gene, confirming CMT4A diagnosis
- Negative Result: Suggests absence of detectable GDAP1 mutations, though other genetic causes may need investigation
- Variant of Uncertain Significance: Requires additional family studies and clinical correlation
- Carrier Status: Identifies individuals who carry one copy of mutated gene without disease symptoms
All results include comprehensive genetic counseling to ensure complete understanding and appropriate next steps.
Test Pricing and Details
| Test Component | Details | Price (USD) |
|---|---|---|
| GDAP1 Gene CMT4A NGS Genetic DNA Test | Comprehensive NGS analysis | $500 (Discounted from $700) |
| Turnaround Time | 3-4 Weeks | Included |
| Sample Type | Blood, Extracted DNA, or FTA Card | Included |
| Genetic Counseling | Pre- and post-test sessions | Included |
Nationwide Testing Availability
We provide comprehensive genetic testing services across the United States with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art laboratories ensure consistent, high-quality results regardless of testing location.
Pre-Test Requirements
To ensure optimal testing outcomes, we recommend:
- Complete clinical history documentation
- Genetic counseling session prior to testing
- Detailed pedigree chart of affected family members
- Neurological examination findings
- Informed consent for genetic testing
Take Control of Your Neurological Health Today
Don’t let uncertainty about neurological symptoms affect your quality of life. The GDAP1 Gene CMT4A NGS Genetic DNA Test provides the clarity needed for proper diagnosis and management of hereditary neuropathies. Our team of genetic specialists and neurologists is ready to guide you through the testing process and help interpret your results.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic test consultation and take the first step toward definitive diagnosis and personalized care.
