T(4;11) q21q23 MLL-AF4 PCR Qualitative Test
Understanding the MLL-AF4 Genetic Test
The T(4;11) q21q23 MLL-AF4 PCR Qualitative Test represents a breakthrough in molecular diagnostics for leukemia detection and classification. This advanced genetic test specifically targets the chromosomal translocation between chromosomes 4 and 11, which results in the fusion of the MLL (Mixed Lineage Leukemia) gene with the AF4 gene. This genetic abnormality is particularly significant in acute lymphoblastic leukemia (ALL) and carries important implications for disease prognosis and treatment selection.
What This Test Measures
This sophisticated molecular test detects the presence of the t(4;11)(q21;q23) chromosomal translocation using Real-Time Polymerase Chain Reaction (PCR) technology. The test specifically identifies:
- The fusion between MLL gene on chromosome 11q23 and AF4 gene on chromosome 4q21
- Presence of MLL-AF4 fusion transcripts in blood or bone marrow samples
- Genetic markers associated with high-risk acute lymphoblastic leukemia
- Molecular evidence for leukemia classification and risk stratification
Who Should Consider This Test?
This genetic test is particularly important for individuals presenting with:
- Suspected or newly diagnosed acute lymphoblastic leukemia
- Infant leukemia cases (under 1 year of age)
- Patients with high white blood cell counts at diagnosis
- Individuals with treatment-resistant leukemia
- Patients requiring precise leukemia classification for treatment planning
- Those with family history of hematological malignancies
Clinical Symptoms That May Indicate Testing Need
- Unexplained fatigue and weakness
- Frequent infections and fever
- Easy bruising or bleeding
- Bone pain or tenderness
- Swollen lymph nodes
- Pale skin and shortness of breath
Benefits of MLL-AF4 Testing
Undergoing the T(4;11) q21q23 MLL-AF4 PCR Qualitative Test provides numerous clinical advantages:
- Accurate Diagnosis: Precise identification of leukemia subtype
- Prognostic Information: Understanding disease severity and progression risk
- Treatment Guidance: Informing chemotherapy and targeted therapy decisions
- Disease Monitoring: Tracking treatment response and minimal residual disease
- Early Intervention: Enabling timely and appropriate therapeutic strategies
- Family Planning: Providing genetic information for hereditary considerations
Understanding Your Test Results
Your MLL-AF4 test results will be interpreted by our expert molecular pathologists and oncologists:
Positive Result
A positive result indicates the presence of the MLL-AF4 fusion gene, confirming the diagnosis of MLL-rearranged acute lymphoblastic leukemia. This finding typically suggests:
- High-risk leukemia classification
- Need for intensive chemotherapy protocols
- Potential consideration for stem cell transplantation
- Close monitoring for treatment response
Negative Result
A negative result indicates the absence of the specific MLL-AF4 fusion, which helps:
- Rule out this specific high-risk leukemia subtype
- Guide alternative diagnostic investigations
- Support standard-risk treatment protocols when appropriate
- Provide reassurance for certain prognostic considerations
Test Pricing and Details
| Test Component | Price (USD) |
|---|---|
| Discount Price | $126 |
| Regular Price | $162 |
| Test Name | T(4;11) q21q23 MLL-AF4 PCR Qualitative Test |
Sample Requirements and Processing
- Sample Type: 3 mL (2 mL minimum) whole blood or bone marrow in Lavender Top (EDTA) tube
- Shipping: Refrigerated transport required – DO NOT FREEZE
- Turnaround Time: Sample Monday/Thursday by 11 AM; Report Wednesday/Saturday
- Mandatory: Complete clinical history must accompany sample
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified laboratories ensures consistent, high-quality testing standards nationwide.
Take Action for Your Health
Don’t wait to get the answers you need for proper leukemia diagnosis and treatment planning. Our expert team is ready to assist you with scheduling your T(4;11) q21q23 MLL-AF4 PCR Qualitative Test.
Call or WhatsApp us today at +1(267) 388-9828 to book your test or speak with our genetic counseling specialists.
Early and accurate genetic testing can make a significant difference in leukemia treatment outcomes. Trust our experienced molecular diagnostics team to provide the precise genetic information your healthcare provider needs for optimal patient care.
