TCF3-PBX1 PCR Qualitative Test for Leukemia Detection
Understanding the TCF3-PBX1 Genetic Test
The T(1;19) q23;p13.3 TCF3-PBX1 PCR Qualitative Test represents a cutting-edge molecular diagnostic approach for detecting specific chromosomal abnormalities associated with acute lymphoblastic leukemia (ALL). This sophisticated test targets the translocation between chromosomes 1 and 19, which creates a fusion gene involving the TCF3 (E2A) gene on chromosome 19 and the PBX1 gene on chromosome 1. This genetic rearrangement is particularly significant in pre-B-cell ALL and serves as a crucial diagnostic and prognostic marker in leukemia management.
What Does This Test Detect?
The TCF3-PBX1 PCR test specifically identifies:
- The presence of the t(1;19) chromosomal translocation
- TCF3-PBX1 fusion gene expression
- Genetic abnormalities driving leukemic cell proliferation
- Specific molecular markers for pre-B-cell ALL classification
Who Should Consider This Test?
This molecular test is recommended for individuals presenting with:
- Unexplained fatigue and weakness persisting for weeks
- Frequent infections or slow recovery from common illnesses
- Unexplained bruising, bleeding, or petechiae
- Bone pain or joint discomfort without clear cause
- Abnormal complete blood count (CBC) results
- Enlarged lymph nodes, spleen, or liver
- Family history of hematological malignancies
- Suspected acute lymphoblastic leukemia based on clinical presentation
Clinical Benefits of TCF3-PBX1 Testing
Choosing the TCF3-PBX1 PCR test provides numerous advantages:
- Precise Diagnosis: Enables accurate classification of leukemia subtypes
- Treatment Guidance: Informs targeted therapeutic approaches
- Prognostic Information: Helps predict disease course and outcomes
- Minimal Residual Disease Monitoring: Tracks treatment response over time
- Early Detection: Identifies genetic abnormalities before full disease manifestation
- Personalized Medicine: Supports individualized treatment plans
Understanding Your Test Results
Your TCF3-PBX1 PCR test results will be interpreted by our expert molecular pathologists:
- Positive Result: Indicates presence of the TCF3-PBX1 fusion gene, confirming the specific genetic abnormality associated with pre-B-cell ALL
- Negative Result: Suggests absence of the specific translocation, though other genetic abnormalities may be present
- Quantitative Interpretation: Results may include information about the level of fusion gene expression
- Clinical Correlation: Results should be interpreted in context with clinical findings and other laboratory tests
Test Pricing and Availability
| Test Name | Regular Price | Discount Price |
|---|---|---|
| T(1;19) q23;p13.3 TCF3-PBX1 PCR Qualitative Test | $162 USD | $126 USD |
Test Specifications
- Turnaround Time: Sample collection Monday/Thursday by 11 AM; Results available Wednesday/Saturday
- Sample Type: 3 mL (2 mL minimum) whole blood or bone marrow in 1 Lavender Top (EDTA) tube
- Shipping Instructions: Ship refrigerated. DO NOT FREEZE
- Pre-test Requirement: Clinical history is mandatory
- Methodology: Real-Time PCR
- Specialty: Oncologist
- Department: Molecular Diagnostics
Nationwide Availability
GGC DNA provides comprehensive molecular diagnostic services across the United States, with convenient testing locations in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network of certified collection centers ensures accessible testing for patients nationwide.
Book Your Test Today
Take the first step toward precise leukemia diagnosis and personalized treatment planning. Our expert team is ready to assist you with scheduling, sample collection, and result interpretation. Contact us today to schedule your TCF3-PBX1 PCR test and gain valuable insights into your hematological health.
Call or WhatsApp: +1(267) 388-9828
Our dedicated patient care coordinators are available to answer your questions, explain the testing process, and help you schedule your appointment at a convenient location near you.
