Sirolimus Rapamycin Test: Essential Therapeutic Drug Monitoring for Transplant Patients
Understanding the Sirolimus Rapamycin Test
The Sirolimus Rapamycin Test represents a critical component in modern transplant medicine, providing precise measurement of sirolimus blood concentrations to optimize immunosuppressive therapy. Sirolimus, also known as rapamycin, is a potent immunosuppressant medication prescribed to prevent organ rejection in transplant recipients. This therapeutic drug monitoring test ensures patients maintain appropriate drug levels within the therapeutic range, balancing effective immunosuppression with minimized side effects.
What Does the Sirolimus Rapamycin Test Measure?
This advanced diagnostic test specifically measures the concentration of sirolimus in whole blood using state-of-the-art Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) technology. The test detects:
- Precise sirolimus blood levels in nanograms per milliliter (ng/mL)
- Trough levels measured 12 hours after the last dose
- Therapeutic range compliance for optimal immunosuppression
- Potential toxic levels requiring dosage adjustment
Who Should Consider Sirolimus Testing?
This test is essential for patients undergoing organ transplantation and receiving sirolimus therapy. Key candidates include:
- Kidney, liver, heart, or lung transplant recipients
- Patients experiencing symptoms of sirolimus toxicity (mouth sores, fatigue, elevated lipids)
- Individuals showing signs of inadequate immunosuppression
- Patients with changing kidney or liver function
- Those taking medications that may interact with sirolimus
- Individuals requiring dosage optimization or adjustment
Clinical Indications and Symptoms
Patients should consider testing when experiencing:
- Unexplained fatigue or weakness
- Mouth ulcers or sores
- Elevated cholesterol or triglyceride levels
- Swelling or fluid retention
- Signs of potential organ rejection
- Changes in kidney or liver function tests
Benefits of Sirolimus Rapamycin Testing
Regular monitoring through this test provides numerous advantages for transplant patients:
- Optimized Medication Dosing: Ensures sirolimus levels remain within therapeutic range
- Reduced Rejection Risk: Maintains adequate immunosuppression to prevent organ rejection
- Toxicity Prevention: Identifies potentially toxic levels before serious side effects occur
- Personalized Treatment: Allows for individualized dosing based on patient metabolism
- Improved Transplant Outcomes: Contributes to long-term transplant success and patient survival
- Cost-Effective Care: Prevents complications that could lead to hospitalization
Understanding Your Test Results
Interpreting sirolimus levels requires careful consideration of individual patient factors:
- Therapeutic Range: Typically 4-12 ng/mL for most transplant patients
- Subtherapeutic Levels: Below 4 ng/mL may indicate inadequate immunosuppression
- Potentially Toxic Levels: Above 15 ng/mL may require dosage adjustment
- Individual Variation: Optimal ranges may vary based on transplant type and time since transplantation
Your healthcare provider will interpret results in the context of your clinical situation, considering factors such as transplant type, time since transplantation, concurrent medications, and overall health status.
Test Information and Pricing
| Test Parameter | Details |
|---|---|
| Test Name | Sirolimus Rapamycin Test |
| Regular Price | $226 USD |
| Discount Price | $162 USD |
| Turnaround Time | Same day (samples submitted by 5 pm) |
| Sample Type | 3 mL whole blood in Lavender Top (EDTA) tube |
| Testing Method | LC-MS/MS |
Sample Collection Instructions
For accurate results, follow these collection guidelines:
- Collect sample 1 hour before next dose (12-hour trough)
- Use 3 mL whole blood in Lavender Top EDTA tube
- Ship refrigerated – DO NOT FREEZE
- Provide date and time of sampling
- Include amount and time of last dose
Nationwide Testing Availability
GGC DNA provides comprehensive Sirolimus Rapamycin testing services across the United States. We have conveniently located branches in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network ensures accessible testing for transplant patients nationwide.
Book Your Sirolimus Rapamycin Test Today
Take control of your transplant health with precise therapeutic drug monitoring. Our experienced team at GGC DNA is committed to providing accurate, reliable testing with rapid turnaround times. Schedule your Sirolimus Rapamycin Test today to ensure optimal immunosuppression and protect your transplant investment.
Call or WhatsApp us now at +1(267) 388-9828 to book your test or for any questions about sirolimus monitoring.
Trust GGC DNA for your therapeutic drug monitoring needs – where precision meets patient care in transplantation medicine.

