Scleroderma Panel Test – Comprehensive Autoimmune Disorder Screening
Understanding Scleroderma and Autoimmune Testing
Scleroderma, also known as systemic sclerosis, is a complex autoimmune disorder characterized by abnormal collagen production leading to skin thickening, internal organ involvement, and vascular complications. The Scleroderma Panel Test represents a crucial diagnostic advancement in rheumatology, providing healthcare providers with essential information for accurate diagnosis and treatment planning.
What Does the Scleroderma Panel Test Measure?
This comprehensive panel specifically detects two critical autoantibodies associated with different forms of scleroderma:
- Scl-70 Antibody (Topoisomerase I): Primarily associated with diffuse systemic sclerosis, this antibody indicates more extensive skin involvement and higher risk of internal organ complications, particularly pulmonary fibrosis.
- Centromere Antibody: Typically found in limited systemic sclerosis (formerly CREST syndrome), this marker correlates with calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias.
Who Should Consider Scleroderma Testing?
This test is recommended for individuals experiencing symptoms suggestive of systemic sclerosis or related autoimmune conditions:
- Progressive skin thickening or tightening, particularly on fingers, hands, and face
- Raynaud’s phenomenon (color changes in fingers with cold exposure)
- Digital ulcers or pitting scars on fingertips
- Gastrointestinal symptoms including difficulty swallowing or acid reflux
- Shortness of breath or persistent cough
- Joint pain, stiffness, or muscle weakness
- Telangiectasias (small red spots on skin surfaces)
- Calcinosis (calcium deposits under the skin)
Clinical Importance and Diagnostic Value
The Scleroderma Panel Test plays a vital role in differentiating between various forms of systemic sclerosis and predicting disease progression. The presence of specific antibodies helps rheumatologists determine the most appropriate treatment approach and monitor disease activity over time.
Key Benefits of Scleroderma Panel Testing
- Early Detection: Identifies autoimmune activity before significant organ damage occurs
- Disease Classification: Helps distinguish between limited and diffuse forms of scleroderma
- Prognostic Information: Specific antibody patterns provide insights into potential disease complications
- Treatment Guidance: Informs targeted therapeutic decisions and monitoring strategies
- Comprehensive Assessment: Evaluates multiple antibody markers in a single test panel
- Rapid Results: Same-day reporting when samples are submitted by 9 am Tuesday or Friday
Test Methodology and Technology
Our Scleroderma Panel utilizes advanced Enzyme Immunoassay (EIA) technology, ensuring high sensitivity and specificity in antibody detection. This methodology provides reliable, reproducible results that meet the highest standards of clinical laboratory testing.
Understanding Your Test Results
Interpreting Scleroderma Panel results requires careful consideration by a qualified rheumatologist or healthcare provider:
- Positive Scl-70 Antibody: Suggests diffuse systemic sclerosis with potential for rapid skin progression and internal organ involvement
- Positive Centromere Antibody: Indicates limited systemic sclerosis, typically with slower progression but significant vascular manifestations
- Double Positive Results: Rare but may indicate overlapping autoimmune conditions requiring comprehensive evaluation
- Negative Results: Do not completely rule out scleroderma, as some patients may have antibody-negative disease
Your healthcare provider will correlate test results with clinical symptoms, physical examination findings, and additional diagnostic studies to establish an accurate diagnosis.
Test Preparation and Sample Requirements
No special preparation is required for the Scleroderma Panel Test. The test requires 3 mL (minimum 1 mL) of serum collected in one serum separator tube (SST). Samples should be shipped refrigerated or frozen to maintain sample integrity.
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Scleroderma Panel Test | $88 USD | $150 USD |
Nationwide Testing Availability
We have diagnostic centers conveniently located throughout the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our extensive network ensures accessible testing services for patients across the country.
Take Control of Your Health Today
Early detection and proper diagnosis are essential for managing scleroderma effectively. Don’t wait for symptoms to progress – take the first step toward understanding your autoimmune health with our comprehensive Scleroderma Panel Test.
Ready to schedule your test? Contact our dedicated healthcare team today to book your appointment or discuss your testing needs. Call or WhatsApp us at +1(267) 388-9828 to speak with a healthcare representative who can answer your questions and help you schedule your Scleroderma Panel Test.
Our commitment to excellence in autoimmune testing ensures you receive accurate, reliable results with the professional support you deserve. Trust General Genetics Corporation for your diagnostic needs and take proactive steps toward better health management.
