Oncomine Chronic Myelomonocytic Leukemia CMML Panel Test
Comprehensive Genetic Analysis for CMML Diagnosis and Management
The Oncomine Chronic Myelomonocytic Leukemia (CMML) Panel Test represents a cutting-edge diagnostic tool in hematologic oncology, specifically designed to address the complex genetic landscape of CMML. This next-generation sequencing (NGS) panel provides comprehensive analysis of 33 key genes known to play critical roles in CMML pathogenesis, offering clinicians unprecedented insights into disease biology and treatment optimization.
What Does the Oncomine CMML Panel Test Measure?
This advanced genetic panel utilizes state-of-the-art NGS technology to detect and analyze:
- Point Mutations: Single nucleotide variations in critical genes
- Insertions and Deletions: Small genetic alterations affecting protein function
- Gene Fusions: Chromosomal rearrangements involving key oncogenes
- Copy Number Variations: Genetic amplifications or deletions
The panel comprehensively evaluates 33 essential genes including ASXL1, TET2, SRSF2, RUNX1, NRAS, DNMT3A, EZH2, and CBL, among others. These genes are specifically selected based on their established roles in CMML development, progression, and treatment response.
Who Should Consider This Test?
The Oncomine CMML Panel Test is recommended for patients presenting with:
- Persistent monocytosis (>1 × 10⁹/L) lasting at least 3 months
- Unexplained cytopenias including anemia, thrombocytopenia, or neutropenia
- Splenomegaly or hepatomegaly without clear etiology
- Constitutional symptoms such as fever, night sweats, or weight loss
- Previous diagnosis of myelodysplastic syndrome or myeloproliferative neoplasm
- Family history of hematologic malignancies
- Patients requiring prognostic stratification for treatment planning
Clinical Benefits of Genetic Testing
Undergoing the Oncomine CMML Panel Test provides numerous clinical advantages:
- Precise Diagnosis: Differentiate CMML from other myelodysplastic/myeloproliferative disorders
- Prognostic Stratification: Identify high-risk genetic profiles requiring aggressive management
- Treatment Guidance: Inform therapeutic decisions based on specific mutation profiles
- Disease Monitoring: Track genetic evolution and treatment response over time
- Clinical Trial Eligibility: Identify patients suitable for targeted therapy trials
- Family Risk Assessment: Evaluate potential hereditary components
Understanding Your Test Results
Your Oncomine CMML Panel results will provide detailed information about:
- Mutation Profile: Specific genetic alterations detected in your sample
- Variant Allele Frequency: Percentage of cells carrying each mutation
- Clinical Significance: Interpretation of how mutations impact disease course
- Therapeutic Implications: Potential targeted treatment options
- Prognostic Information: Risk stratification based on mutation combinations
Our expert molecular pathologists and hematologists will provide comprehensive interpretation of your results, ensuring you understand the clinical implications and next steps in your care journey.
Test Pricing and Availability
| Test Name | Regular Price | Discount Price |
|---|---|---|
| Oncomine Chronic Myelomonocytic Leukemia CMML Panel Test | $1138 USD | $1024 USD |
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including:
- New York City and surrounding areas
- Los Angeles and Southern California
- Chicago and the Midwest region
- Houston and Texas medical centers
- Phoenix and Arizona healthcare facilities
- Philadelphia and the Northeast corridor
- All other major US cities and regions
Sample Requirements and Processing
Sample Type: 3 mL (2 mL minimum) whole blood OR bone marrow in 1 lavender top (EDTA) tube
Shipping Instructions: Ship refrigerated. DO NOT FREEZE
Required Documentation: Duly filled NGS Test Requisition Form (Form 40) is mandatory
Turnaround Time: Samples accepted by 1st/16th of every month; Reports delivered 15th/30th of same month
Take Control of Your CMML Management Today
Don’t let uncertainty dictate your leukemia management. The Oncomine CMML Panel Test provides the genetic clarity needed for informed treatment decisions and personalized care planning. Our team of dedicated specialists is ready to assist you in navigating your diagnostic journey.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your test or speak with our genetic counseling team.
Early genetic characterization can significantly impact treatment outcomes and quality of life. Take the first step toward comprehensive CMML management by booking your Oncomine CMML Panel Test today.
