Next Generation Sequencing Amyotrophic Lateral Sclerosis Test
Comprehensive Genetic Screening for Motor Neuron Disease
The Next Generation Sequencing Amyotrophic Lateral Sclerosis (NGS ALS) Test represents a breakthrough in genetic diagnostics for progressive motor neuron disorders. This advanced screening method utilizes cutting-edge next-generation sequencing technology to analyze 29 critical genes associated with ALS development, providing unprecedented insights into hereditary risk factors and disease mechanisms.
What This Revolutionary Test Measures
Our comprehensive NGS ALS test examines multiple genetic markers including:
- ALS2, ANG, ATXN2, C9orf72 – Primary ALS-associated genes
- CHCHD10, CHMP2B, DCTN1, ERBB4 – Secondary risk factor genes
- FIG4, FUS, HNRNPA1, MATR3 – RNA processing and protein aggregation genes
- NEFH, OPTN, PFN1, PRPH – Cytoskeletal and neuronal function genes
- SETX, SIGMAR1, SMN1, SOD1 – Oxidative stress and motor neuron survival genes
- SPG11, SQSTM1, TARDBP, TBK1 – Autophagy and protein degradation genes
- TRPM7, TUBA4A, UBQLN2, VAPB, VCP – Additional ALS risk factor genes
Who Should Consider ALS Genetic Testing?
Primary Candidates Include:
- Individuals with family history of ALS or motor neuron disease
- Patients experiencing early symptoms including muscle weakness, twitching, or cramping
- Those with unexplained difficulty with speech, swallowing, or breathing
- Individuals planning family who have ALS in their genetic background
- Patients with progressive muscle atrophy without clear diagnosis
- Those seeking comprehensive genetic counseling for neurological conditions
Significant Benefits of NGS ALS Testing
Early Detection and Intervention
Identifying genetic risk factors enables proactive monitoring and early intervention strategies, potentially slowing disease progression and improving quality of life.
Personalized Treatment Planning
Genetic insights allow neurologists to develop targeted treatment approaches based on specific genetic mutations and individual risk profiles.
Family Planning Guidance
Understanding hereditary patterns provides crucial information for family planning decisions and genetic counseling.
Comprehensive Risk Assessment
Multi-gene analysis offers a complete picture of genetic susceptibility beyond single-gene testing limitations.
Understanding Your Test Results
Positive Results Interpretation
A positive result indicates the presence of known ALS-associated genetic mutations. This information should be discussed with a qualified neurologist and genetic counselor to develop appropriate monitoring and management strategies.
Negative Results Meaning
Negative results reduce the likelihood of hereditary ALS but do not completely eliminate the possibility of developing sporadic forms of the disease. Regular neurological evaluations remain important.
Variant of Uncertain Significance
Some genetic variations may have unknown clinical significance. These findings require ongoing research and may be reclassified as more data becomes available.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $586 |
| Regular Price | $650 |
Testing Process Details
- Turnaround Time: Sample collected daily by 9 AM; Reports available in 40 working days
- Sample Type: 10 mL (5 mL minimum) whole blood from 2 Lavender Top (EDTA) tubes
- Shipping: Refrigerated transport required – DO NOT FREEZE samples
- Mandatory Documentation: Duly filled Whole Exome Sequencing Consent Form (Form 37)
Nationwide Testing Availability
We have diagnostic centers across all major cities in the United States, including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network ensures accessible genetic testing services with consistent quality standards nationwide.
Take Control of Your Neurological Health
Early genetic screening for ALS can provide life-changing insights and peace of mind. Our expert team of neurologists and genetic counselors are available to discuss your results and provide comprehensive guidance.
Ready to schedule your NGS ALS Test? Call our genetic specialists today at +1(267) 388-9828 or book your appointment online. Take the first step toward understanding your genetic risk factors and proactive health management.
Don’t wait for symptoms to progress – knowledge is your most powerful tool in managing neurological health. Contact us now to schedule your comprehensive genetic screening and receive professional genetic counseling with your results.
