NPM1 Gene Mutation Test
Understanding NPM1 Gene Mutation Testing
The NPM1 Gene Mutation Test represents a cutting-edge molecular diagnostic approach specifically designed to detect mutations in the Nucleophosmin 1 gene, which plays a crucial role in acute myeloid leukemia (AML) development and progression. This sophisticated test provides hematologists and oncologists with essential genetic information that directly impacts treatment strategies and patient outcomes in leukemia management.
What Does the NPM1 Gene Mutation Test Detect?
This advanced diagnostic test specifically identifies mutations in the NPM1 gene, particularly focusing on the characteristic frameshift mutations in exon 12 that are strongly associated with normal karyotype acute myeloid leukemia. The test measures:
- Presence of NPM1 gene mutations in blood or bone marrow samples
- Specific mutation types that influence treatment response
- Genetic markers that help classify AML subtypes
- Molecular indicators for prognosis assessment
Who Should Consider NPM1 Gene Mutation Testing?
This test is particularly important for individuals presenting with symptoms suggestive of acute myeloid leukemia or those with confirmed AML diagnosis. Consider testing if you experience:
- Unexplained fatigue and weakness that persists
- Frequent infections or prolonged recovery from illnesses
- Easy bruising or unusual bleeding tendencies
- Pale skin or shortness of breath
- Bone pain or tenderness
- Unexplained weight loss or loss of appetite
- Patients with newly diagnosed AML requiring genetic stratification
- Individuals undergoing AML treatment monitoring
Key Benefits of NPM1 Gene Mutation Testing
Choosing the NPM1 Gene Mutation Test provides numerous advantages for patients and healthcare providers:
- Accurate Diagnosis: Precisely identifies NPM1 mutations critical for AML classification
- Treatment Guidance: Helps determine optimal chemotherapy and targeted therapy approaches
- Prognostic Information: Provides valuable insights into disease progression and treatment response
- Minimal Residual Disease Monitoring: Enables tracking of treatment effectiveness over time
- Personalized Medicine: Supports development of individualized treatment plans
- Rapid Results: Quick turnaround with reports available Wednesdays and Saturdays
Understanding Your Test Results
Your NPM1 Gene Mutation Test results will provide clear guidance for your healthcare team:
- Positive Result: Indicates presence of NPM1 mutation, typically associated with better response to certain chemotherapy regimens
- Negative Result: Absence of NPM1 mutation may suggest alternative AML subtypes requiring different treatment approaches
- Quantitative Results: Some tests provide mutation burden information for monitoring treatment response
- Clinical Correlation: Results should always be interpreted by your hematologist or oncologist in context of other diagnostic findings
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $138 |
| Regular Price | $200 |
Test Specifications
- Turnaround Time: Samples accepted Monday/Thursday by 11 AM; Reports available Wednesday/Saturday
- Sample Type: 5 mL (3 mL min.) whole blood / Bone marrow in 1 Lavender Top (EDTA) tube
- Shipping: Refrigerated transport required. DO NOT FREEZE
- Required Documentation: Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our nationwide network ensures accessible testing for patients throughout the country.
Book Your NPM1 Gene Mutation Test Today
Take the first step toward comprehensive leukemia diagnosis and personalized treatment planning. Our experienced team is ready to assist you with scheduling and answer any questions about the testing process.
Call or WhatsApp us today: +1(267) 388-9828
Early detection and accurate genetic profiling can make a significant difference in leukemia treatment outcomes. Trust our advanced molecular diagnostics laboratory for reliable NPM1 mutation testing with rapid turnaround times and expert interpretation.
