Myeloproliferative Neoplasia MPN Extended Profile Test
Comprehensive Blood Cancer Genetic Screening
The Myeloproliferative Neoplasia MPN Extended Profile Test represents a cutting-edge diagnostic approach for identifying and characterizing blood cancers known as myeloproliferative neoplasms. These rare hematological conditions involve the abnormal production of blood cells in the bone marrow, leading to serious health complications if left undiagnosed. Our comprehensive testing panel utilizes advanced molecular techniques to detect specific genetic mutations that drive these disorders, providing clinicians with essential information for accurate diagnosis and targeted treatment planning.
What This Advanced Test Measures
Our MPN Extended Profile employs sophisticated Real Time PCR and Sequencing methodologies to detect five critical genetic markers:
- JAK2 V617F Mutation: The most common mutation in polycythemia vera and essential thrombocythemia
- JAK2 Exon 12 Mutations: Additional JAK2 variants associated with MPN development
- BCR-ABL PCR Qualitative: Detects the Philadelphia chromosome fusion gene characteristic of chronic myeloid leukemia
- CALR Mutations: Calreticulin gene mutations frequently found in essential thrombocythemia and primary myelofibrosis
- MPL Mutations: Thrombopoietin receptor mutations linked to specific MPN subtypes
Who Should Consider This Genetic Screening
This comprehensive test is recommended for individuals experiencing:
- Unexplained elevated blood counts (red cells, white cells, or platelets)
- Persistent fatigue and weakness without clear cause
- Enlarged spleen (splenomegaly) detected during physical examination
- Night sweats, itching after warm showers (aquagenic pruritus)
- Bone pain or abdominal discomfort
- Family history of blood disorders or hematological cancers
- Abnormal blood smear findings suggesting myeloproliferative disease
Key Benefits of MPN Genetic Testing
- Accurate Diagnosis: Differentiates between various MPN subtypes for precise classification
- Personalized Treatment: Guides targeted therapy selection based on specific mutation profiles
- Prognostic Information: Provides insights into disease progression and potential complications
- Early Detection: Identifies genetic abnormalities before advanced symptoms develop
- Treatment Monitoring: Helps track response to therapy and detect emerging resistance
Understanding Your Test Results
Your MPN Extended Profile results will provide detailed information about the presence or absence of specific genetic mutations. A positive result for any of the tested mutations confirms the diagnosis of a myeloproliferative neoplasm and helps classify the specific subtype. Negative results across all markers may suggest alternative diagnoses or rare MPN variants not covered by this panel. Your hematologist or oncologist will interpret these findings in the context of your clinical presentation, blood counts, and other diagnostic tests to develop a comprehensive treatment strategy tailored to your specific genetic profile.
Test Pricing Information
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $400 |
| Regular Price | $550 |
Convenient Testing Locations Nationwide
We have diagnostic centers conveniently located across the United States, serving major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art facilities ensure consistent, high-quality testing standards regardless of location.
Schedule Your MPN Testing Today
Take control of your hematological health with our comprehensive MPN Extended Profile Test. Our experienced team is ready to assist you in scheduling your appointment and answering any questions about the testing process. Contact us today at +1(267) 388-9828 to book your test or discuss your testing needs with our genetic counseling specialists.
Sample Requirements: 8 mL (4 mL minimum) whole blood in 2 Lavender top (EDTA) tubes. Ship refrigerated. DO NOT FREEZE. Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Turnaround Time: Sample received by Monday 9:00 AM; Report delivered by Saturday
