Metanephrines Free Plasma Test
Comprehensive Diagnostic Testing for Adrenal Tumors
The Metanephrines Free Plasma Test represents a breakthrough in endocrine diagnostics, offering unparalleled accuracy in detecting pheochromocytoma and paraganglioma tumors. These rare but potentially life-threatening neuroendocrine tumors originate from chromaffin cells and can cause severe, often episodic, hypertension through excessive catecholamine production. Our advanced testing methodology provides clinicians with reliable biomarkers for early detection and management of these challenging conditions.
What Does This Test Measure?
The Metanephrines Free Plasma Test utilizes sophisticated liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology to precisely quantify three critical biomarkers:
- Metanephrine Free – The O-methylated metabolite of epinephrine
- Normetanephrine Free – The O-methylated metabolite of norepinephrine
- 3-Methoxytyramine – The O-methylated metabolite of dopamine
These free metanephrines serve as stable, sensitive markers that reflect catecholamine production from adrenal medulla and extra-adrenal chromaffin tissue, providing superior diagnostic accuracy compared to traditional catecholamine measurements.
Who Should Consider This Test?
This specialized diagnostic test is recommended for individuals experiencing:
- Unexplained or treatment-resistant hypertension
- Episodic symptoms including severe headaches, palpitations, and sweating
- Adrenal incidentalomas discovered on imaging studies
- Family history of pheochromocytoma, paraganglioma, or related genetic syndromes
- Symptoms suggestive of catecholamine excess despite normal blood pressure
- Monitoring following surgical resection of neuroendocrine tumors
Clinical Benefits and Advantages
The Metanephrines Free Plasma Test offers numerous clinical advantages:
- Superior Sensitivity – Detects over 99% of pheochromocytomas
- Enhanced Specificity – Reduces false-positive results common with older methods
- Early Detection – Identifies tumors before they become symptomatic
- Monitoring Capability – Tracks treatment response and disease recurrence
- Genetic Correlation – Supports evaluation of hereditary tumor syndromes
Understanding Your Test Results
Interpretation of Metanephrines Free Plasma results requires careful clinical correlation:
- Normal Results – Typically exclude clinically significant pheochromocytoma
- Mild Elevations – May require repeat testing or additional evaluation
- Significant Elevations – Strongly suggestive of pheochromocytoma or paraganglioma
- Pattern Analysis – Specific patterns may indicate tumor location or genetic predisposition
All abnormal results should be discussed with your healthcare provider for proper interpretation and management planning.
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Metanephrines Free Plasma Test | $212 USD | $300 USD |
Nationwide Testing Availability
GGC DNA provides comprehensive Metanephrines Free Plasma testing services across the United States, with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our state-of-the-art laboratories ensure consistent, reliable results with rapid turnaround times.
Sample Collection Requirements
Proper sample collection is crucial for accurate results:
- Sample Volume: 4 mL (2 mL minimum) plasma from 2 Lavender top (EDTA) tubes
- Patient Preparation: Overnight fasting mandatory
- Collection Position: Patient in supine position after minimum 30 minutes of rest
- Sample Handling: Immediate immersion in ice water, plasma separation within 30 minutes
- Shipping: Refrigerated or frozen transport
- Turnaround Time: Sample Wednesday/Saturday by 9 AM; Report Friday/Tuesday
Pre-Test Preparation Guidelines
To ensure accurate results, patients must follow these preparation instructions:
- Avoid Medications: Labetalol, Sotalol, Acetaminophen, Methyldopa, Antidepressants
- Eliminate Stimulants: Ephedrine, Amphetamine, Nicotine, Caffeine
- Dietary Restrictions: Avoid bananas, pineapple, nuts, cereals for 72 hours prior
- Consult Your Physician before discontinuing any prescribed medications
Book Your Test Today
Take control of your health with the most advanced diagnostic testing available. Our experienced genetic specialists and endocrinology team are ready to provide comprehensive evaluation and support. Contact us today to schedule your Metanephrines Free Plasma Test and receive the accurate diagnosis you deserve.
Call or WhatsApp: +1(267) 388-9828
Our dedicated patient care coordinators are available to answer your questions, assist with scheduling, and provide guidance on test preparation and insurance coverage.