Leukocyte Adhesion Deficiency LAD I & II Test
Understanding Leukocyte Adhesion Deficiency Testing
Leukocyte Adhesion Deficiency (LAD) represents a group of rare inherited immunodeficiency disorders characterized by defects in white blood cell adhesion and migration. The LAD I & II Test is a sophisticated diagnostic tool that plays a crucial role in identifying these life-threatening conditions early, enabling timely intervention and management strategies.
What is Leukocyte Adhesion Deficiency?
Leukocyte Adhesion Deficiency encompasses genetic disorders where white blood cells cannot properly adhere to blood vessel walls and migrate to sites of infection. This impairment severely compromises the body’s ability to fight infections, leading to recurrent bacterial and fungal infections, delayed wound healing, and persistent inflammation.
What the Test Measures and Detects
Our comprehensive LAD I & II Test utilizes advanced flow cytometry technology to evaluate specific cell surface markers essential for proper immune function:
- CD11a Analysis: Measures integrin alpha L chain expression critical for lymphocyte adhesion
- CD11b Assessment: Evaluates complement receptor type 3 (CR3) essential for phagocyte function
- CD18 Detection: Analyzes beta-2 integrin chain crucial for leukocyte adhesion
- CD15s Evaluation: Assesses sialyl Lewis X antigen important for selectin-mediated rolling
Who Should Consider This Test
This specialized test is recommended for individuals presenting with symptoms suggestive of immunodeficiency disorders:
Clinical Indications and Symptoms
- Recurrent bacterial infections without pus formation
- Delayed separation of the umbilical cord beyond 3 weeks
- Persistent skin infections and poor wound healing
- Severe gingivitis and periodontal disease
- Elevated white blood cell counts (leukocytosis)
- History of omphalitis (umbilical cord infection)
- Recurrent respiratory infections
- Failure to thrive in infants and children
Benefits of Taking the LAD I & II Test
Early diagnosis through comprehensive LAD testing offers numerous advantages for patients and healthcare providers:
- Accurate Diagnosis: Provides definitive identification of LAD types I and II
- Early Intervention: Enables prompt treatment initiation to prevent complications
- Family Planning Guidance: Assists in genetic counseling for affected families
- Treatment Optimization: Guides appropriate antimicrobial prophylaxis
- Prognostic Information: Helps predict disease severity and outcomes
- Bone Marrow Transplant Consideration: Identifies candidates for curative therapy
Understanding Your Test Results
Interpreting LAD I & II test results requires specialized medical expertise, but general guidance includes:
Normal Results
Normal expression of CD11a, CD11b, CD18, and CD15s indicates proper leukocyte adhesion capabilities and suggests the absence of LAD disorders.
Abnormal Findings
- LAD Type I: Markedly reduced or absent CD18 expression with corresponding decreases in CD11a and CD11b
- LAD Type II: Normal CD18 expression but absent CD15s (sialyl Lewis X antigen)
- Intermediate Forms: Partial deficiency patterns indicating milder disease variants
Clinical Correlation
Test results should always be interpreted in conjunction with clinical symptoms, family history, and additional laboratory findings by a qualified immunologist or pediatric specialist.
Test Pricing and Details
| Test Component | Price Type | Amount (USD) |
|---|---|---|
| Leukocyte Adhesion Deficiency LAD I & II Test | Discount Price | $138 |
| Leukocyte Adhesion Deficiency LAD I & II Test | Regular Price | $238 |
Turnaround Time
Sample Daily by 9 am; Report Next Working Day
Sample Requirements
- 3 mL (2 mL min.) whole blood in 1 Lavender Top (EDTA) tube
- 3 mL (2 mL min.) whole blood in 1 Green Top (Sodium Heparin) tube
- Mix thoroughly & ship immediately at 18-22°C
- DO NOT REFRIGERATE OR FREEZE
- Specify time of draw and date in test request form
Mandatory Requirements
It is mandatory to provide clinical details & CBC report for accurate test interpretation.
Nationwide Testing Availability
We have branches across the United States, including all major metropolitan areas. Our state-of-the-art flow cytometry facilities ensure consistent, high-quality testing results regardless of location. Whether you’re in New York, Los Angeles, Chicago, Houston, Phoenix, or any other major city, access to this critical diagnostic test is readily available.
Book Your Test Today
Don’t delay in getting the answers you need for proper immune system evaluation. Our specialized team is ready to assist you with scheduling and answer any questions about the Leukocyte Adhesion Deficiency LAD I & II Test.
Call or WhatsApp: +1(267) 388-9828
Take the first step toward accurate diagnosis and effective management of immunodeficiency concerns. Our experienced pediatric immunology specialists and advanced flow cytometry technology provide the comprehensive assessment needed for optimal patient care.
