TNFRSF1A Gene Periodic Fever Autosomal Dominant NGS Genetic DNA Test
Understanding TNFRSF1A Genetic Testing
The TNFRSF1A Gene Periodic Fever Autosomal Dominant NGS Genetic DNA Test represents a breakthrough in molecular diagnostics for hereditary autoinflammatory disorders. This advanced genetic analysis specifically targets the TNFRSF1A gene, which plays a critical role in regulating the body’s inflammatory response. When mutations occur in this gene, they can lead to TRAPS (Tumor Necrosis Factor Receptor-Associated Periodic Syndrome), a rare but significant condition characterized by recurrent fever episodes and systemic inflammation.
Using state-of-the-art Next-Generation Sequencing (NGS) technology, our test provides comprehensive analysis of the entire TNFRSF1A gene with exceptional accuracy and precision. This approach allows for the detection of both common and rare mutations that might be missed by conventional testing methods. The importance of this test lies in its ability to provide definitive diagnosis for individuals suffering from unexplained recurrent fevers, enabling targeted treatment and improved quality of life.
What Does the Test Detect?
The TNFRSF1A Gene Periodic Fever Autosomal Dominant NGS Genetic DNA Test specifically identifies:
- Point mutations in the TNFRSF1A gene coding regions
- Small insertions and deletions affecting gene function
- Missense mutations that alter protein structure
- Autosomal dominant inheritance patterns
- Genetic variants associated with TRAPS syndrome
This comprehensive analysis examines all exons and flanking intronic regions of the TNFRSF1A gene, ensuring no potential mutation goes undetected. The test’s high sensitivity and specificity make it the gold standard for diagnosing TRAPS and related periodic fever syndromes.
Who Should Consider This Test?
Clinical Indications and Symptoms
This genetic test is recommended for individuals experiencing:
- Recurrent fever episodes lasting 1-3 weeks
- Unexplained abdominal pain and cramping
- Migratory muscle pain and joint inflammation
- Characteristic skin rashes, particularly erythematous patches
- Conjunctivitis or periorbital edema
- Family history of similar periodic fever symptoms
- Elevated inflammatory markers during fever episodes
- Poor response to conventional anti-inflammatory treatments
Family History Considerations
Individuals with a family history of autosomal dominant inheritance patterns of periodic fever should strongly consider testing. The test is particularly important for:
- First-degree relatives of diagnosed TRAPS patients
- Individuals planning pregnancy with family history of periodic fever
- Patients with unexplained inflammatory symptoms despite normal routine testing
Benefits of TNFRSF1A Genetic Testing
Undergoing the TNFRSF1A Gene Periodic Fever Autosomal Dominant NGS Genetic DNA Test offers numerous advantages:
Accurate Diagnosis
Provides definitive molecular confirmation of TRAPS, eliminating diagnostic uncertainty and reducing unnecessary medical investigations.
Personalized Treatment Planning
Enables targeted therapeutic approaches, including interleukin-1 inhibitors and other biologic agents specifically effective for TRAPS management.
Family Risk Assessment
Facilitates genetic counseling and risk assessment for family members, allowing for early intervention and preventive measures.
Improved Quality of Life
Early diagnosis and appropriate treatment can significantly reduce symptom frequency and severity, preventing long-term complications such as amyloidosis.
Understanding Your Test Results
Positive Result Interpretation
A positive result indicates the presence of a pathogenic mutation in the TNFRSF1A gene, confirming the diagnosis of TRAPS. Our genetic counseling team will:
- Explain the specific mutation identified and its clinical significance
- Discuss inheritance patterns and family implications
- Provide personalized treatment recommendations
- Coordinate with your healthcare provider for comprehensive care
Negative Result Interpretation
A negative result suggests that no disease-causing mutations were detected in the TNFRSF1A gene. However, this does not completely rule out TRAPS or other periodic fever syndromes. Further evaluation may be recommended based on clinical presentation.
Variant of Uncertain Significance
In some cases, genetic variants of uncertain significance may be identified. Our team provides comprehensive counseling to help understand these findings and recommend appropriate follow-up.
Test Pricing and Details
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
Nationwide Availability
We have branches across the United States, making genetic testing accessible to patients in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art laboratories ensure consistent, high-quality results regardless of location.
Take Control of Your Health Today
Don’t let unexplained recurrent fevers and inflammatory symptoms control your life. The TNFRSF1A Gene Periodic Fever Autosomal Dominant NGS Genetic DNA Test provides the answers you need for proper diagnosis and effective treatment. Our team of genetic specialists and counselors are ready to support you through every step of the testing process.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your appointment or book your test online. Take the first step toward understanding your genetic health and achieving better symptom management.
Remember, early diagnosis and appropriate treatment can significantly improve quality of life and prevent serious complications. Trust the experts at General Genetics Corporation for accurate, reliable genetic testing you can count on.
