RAG2 Gene Combined Cellular and Humoral Immune Defects with Granulomas NGS Genetic DNA Test
Comprehensive Genetic Analysis for Immune System Disorders
The RAG2 Gene Combined Cellular and Humoral Immune Defects with Granulomas NGS Genetic DNA Test represents a breakthrough in immunogenetics diagnostics. This advanced test specifically targets mutations in the RAG2 (Recombination-Activating Gene 2) gene, which plays a critical role in V(D)J recombination—the fundamental process responsible for generating diverse T-cell and B-cell receptors essential for adaptive immunity.
What This Test Measures and Detects
Our state-of-the-art Next-Generation Sequencing (NGS) technology comprehensively analyzes the RAG2 gene to identify:
- Pathogenic variants causing combined immunodeficiency
- Mutations affecting both cellular (T-cell) and humoral (B-cell) immunity
- Genetic abnormalities leading to granuloma formation
- Inherited patterns of immune system dysfunction
- Specific nucleotide changes impacting V(D)J recombination efficiency
Who Should Consider This Test
This genetic test is particularly recommended for individuals presenting with:
- Recurrent, severe, or unusual infections starting in infancy or early childhood
- Failure to thrive and persistent diarrhea
- Autoimmune manifestations and chronic inflammation
- Granulomatous skin lesions or organ involvement
- Family history of primary immunodeficiency disorders
- Unexplained lymphopenia or abnormal lymphocyte subsets
- Poor response to routine vaccinations
Clinical Benefits of RAG2 Genetic Testing
Undergoing this comprehensive genetic analysis provides numerous advantages:
- Accurate Diagnosis: Precise identification of the underlying genetic cause of immune dysfunction
- Personalized Treatment: Guidance for targeted therapies and management strategies
- Family Planning: Essential information for genetic counseling and reproductive decisions
- Early Intervention: Opportunity for prompt treatment before severe complications develop
- Transplantation Planning: Critical data for hematopoietic stem cell transplantation considerations
- Prognostic Information: Better understanding of disease progression and long-term outcomes
Understanding Your Test Results
Our comprehensive genetic report provides detailed interpretation of your RAG2 gene analysis:
- Positive Result: Identifies specific pathogenic variants requiring immediate medical attention and specialized immunology care
- Negative Result: Suggests alternative causes for immune symptoms, guiding further diagnostic evaluation
- Variant of Uncertain Significance: Requires additional family studies and clinical correlation
- Carrier Status: Important information for family members and genetic counseling
All results are accompanied by detailed explanations and recommendations from our certified genetic counselors.
Test Pricing and Details
| Test Component | Details |
|---|---|
| Test Name | RAG2 Gene Combined Cellular and Humoral Immune Defects with Granulomas NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements
To ensure optimal testing accuracy and interpretation:
- Complete clinical history documentation
- Genetic counseling session to create detailed family pedigree
- Discussion of testing implications and potential outcomes
- Informed consent process
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified collection centers ensures accessible testing regardless of your location.
Take the Next Step Toward Better Health
Don’t let uncertainty about immune system disorders compromise your quality of life. Our RAG2 genetic test provides the clarity needed for effective medical management and treatment planning. Contact our genetic specialists today to schedule your comprehensive evaluation.
Book Your Test Today: Call or WhatsApp +1(267) 388-9828 to speak with our genetic counseling team and schedule your appointment. Take control of your immune health with precise genetic diagnostics from General Genetics Corporation.
