NDE1 Gene Lissencephaly Type 4 with Microcephaly NGS Genetic DNA Test
Comprehensive Genetic Testing for Neurological Development Disorders
The NDE1 Gene Lissencephaly Type 4 with Microcephaly NGS Genetic DNA Test represents a breakthrough in neurological genetic diagnostics, offering families and healthcare providers critical insights into rare developmental brain disorders. This advanced genetic analysis specifically targets mutations in the NDE1 gene, which plays a vital role in neuronal migration and brain development during early fetal stages.
What This Test Measures and Detects
Our NGS-based genetic test employs cutting-edge Next-Generation Sequencing technology to comprehensively analyze the NDE1 gene for pathogenic variants associated with:
- Lissencephaly type 4 (smooth brain surface malformations)
- Primary microcephaly (significantly reduced head circumference)
- Neuronal migration defects
- Cortical development abnormalities
- Autosomal recessive inheritance patterns
The test identifies single nucleotide variants, small insertions/deletions, and copy number variations within the NDE1 gene region, providing a comprehensive genetic profile for accurate diagnosis and family planning.
Who Should Consider This Genetic Test
This specialized genetic test is recommended for individuals and families experiencing:
- Infants or children with developmental delays and neurological symptoms
- Family history of lissencephaly or microcephaly
- Unexplained seizures or epilepsy in early childhood
- Significant developmental regression
- Multiple family members with neurological disorders
- Couples planning pregnancy with known family history of NDE1-related conditions
- Individuals with confirmed microcephaly seeking genetic confirmation
Clinical Symptoms and Indications
Patients with NDE1 gene mutations typically present with:
- Severe intellectual disability
- Developmental delays in motor and cognitive functions
- Refractory epilepsy and seizure disorders
- Feeding difficulties and failure to thrive
- Abnormal muscle tone (hypotonia or hypertonia)
- Vision and hearing impairments
- Limited speech development
Benefits of NDE1 Genetic Testing
Comprehensive Diagnostic Advantages
Undergoing the NDE1 Gene Lissencephaly Type 4 with Microcephaly NGS Genetic DNA Test provides numerous clinical benefits:
- Accurate Diagnosis: Confirms or rules out NDE1-related disorders with high precision
- Family Planning Guidance: Enables informed reproductive decisions for at-risk families
- Personalized Management: Helps healthcare providers develop targeted treatment strategies
- Early Intervention: Facilitates timely therapeutic interventions and support services
- Genetic Counseling: Provides families with comprehensive understanding of inheritance patterns
- Research Contribution: Contributes to ongoing scientific understanding of rare neurological disorders
Understanding Your Test Results
Interpreting Genetic Findings
Our comprehensive genetic counseling service helps you understand your NDE1 test results:
- Positive Result: Indicates the presence of pathogenic NDE1 gene mutations associated with lissencephaly type 4 and microcephaly
- Negative Result: Suggests no detectable NDE1 mutations, though other genetic causes should be considered
- Variant of Uncertain Significance: Identifies genetic changes whose clinical significance requires further investigation
- Carrier Status: Determines if individuals carry one copy of a mutated NDE1 gene without showing symptoms
Our genetic counselors provide detailed explanations of results, inheritance patterns, and implications for family members during post-test counseling sessions.
Test Details and Pricing
| Test Information | Details |
|---|---|
| Test Name | NDE1 Gene Lissencephaly Type 4 with Microcephaly NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements
Before scheduling your NDE1 genetic test, we require:
- Complete clinical history of the patient
- Genetic counseling session to create a detailed family pedigree chart
- Documentation of affected family members with similar neurological symptoms
- Current neurological assessment and imaging studies when available
Nationwide Testing Availability
We proudly offer comprehensive genetic testing services across the United States with convenient locations in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network of certified genetic counselors and neurological specialists ensures you receive expert care regardless of your location.
Take the Next Step Toward Genetic Clarity
Don’t let uncertainty about neurological conditions affect your family’s future. Our NDE1 Gene Lissencephaly Type 4 with Microcephaly NGS Genetic DNA Test provides the answers you need for informed healthcare decisions and family planning.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your test. Our compassionate team is ready to guide you through every step of the genetic testing process, from initial consultation to comprehensive result interpretation.
Early genetic diagnosis can make a significant difference in managing neurological conditions and planning for the future. Contact us now to begin your journey toward genetic understanding and peace of mind.
