MLH1 Gene Colorectal Cancer Hereditary Nonpolyposis Type 2 NGS Genetic DNA Test
Comprehensive Genetic Testing for Lynch Syndrome Detection
The MLH1 Gene Colorectal Cancer Hereditary Nonpolyposis Type 2 NGS Genetic DNA Test represents a cutting-edge approach to hereditary cancer risk assessment. This specialized genetic examination focuses on identifying mutations in the MLH1 gene, which plays a critical role in DNA mismatch repair. When this gene malfunctions, it significantly increases an individual’s susceptibility to developing Lynch Syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC).
What Does This Test Measure and Detect?
This advanced genetic test specifically targets the MLH1 gene using Next-Generation Sequencing (NGS) technology to identify:
- Pathogenic mutations in the MLH1 gene associated with Lynch Syndrome
- DNA mismatch repair deficiencies that predispose to multiple cancer types
- Specific genetic variants that increase colorectal cancer risk by up to 80%
- Mutations that elevate risks for endometrial, ovarian, gastric, and other cancers
- Inherited genetic patterns that affect multiple family generations
Who Should Consider This Genetic Test?
This test is particularly recommended for individuals who exhibit:
- Personal history of colorectal cancer diagnosed before age 50
- Family history of multiple relatives with Lynch Syndrome-associated cancers
- Presence of colorectal cancer in two or more generations
- Diagnosis of endometrial cancer before age 50
- Multiple primary cancers in the same individual
- Abnormal tumor testing suggesting mismatch repair deficiency
- Known family history of MLH1 gene mutations
Clinical Benefits of MLH1 Genetic Testing
Undergoing MLH1 genetic testing provides numerous significant advantages:
- Early Risk Identification: Detect genetic predisposition before cancer development
- Personalized Screening: Implement targeted surveillance protocols based on genetic risk
- Preventive Strategies: Develop proactive health management plans
- Family Planning Guidance: Make informed reproductive decisions
- Treatment Optimization: Guide therapeutic approaches for affected individuals
- Family Member Testing: Identify at-risk relatives for early intervention
Understanding Your Test Results
Your MLH1 genetic test results will fall into one of several categories:
- Positive Result: Indicates the presence of a pathogenic MLH1 mutation, confirming Lynch Syndrome diagnosis and necessitating enhanced cancer surveillance
- Negative Result: No mutation detected, though family history may still warrant continued monitoring
- Variant of Uncertain Significance (VUS): Identifies a genetic change with unknown clinical implications requiring ongoing research and family studies
- No Mutation Detected in Affected Individual: May suggest alternative genetic causes or non-hereditary factors
Test Information and Pricing
| Test Component | Details |
|---|---|
| Test Name | MLH1 Gene Colorectal Cancer Hereditary Nonpolyposis Type 2 NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements and Genetic Counseling
Before undergoing MLH1 genetic testing, patients should complete:
- Comprehensive clinical history documentation
- Genetic counseling session with certified genetic counselor
- Development of detailed pedigree chart mapping family cancer history
- Discussion of potential implications for family members
- Informed consent process explaining benefits, limitations, and possible outcomes
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network of certified genetic counselors and healthcare providers ensures accessible, high-quality genetic testing services nationwide.
Take Control of Your Genetic Health Today
Don’t wait to understand your genetic cancer risk. Early detection through MLH1 genetic testing can provide life-saving information for you and your family. Our team of genetic specialists is ready to guide you through the testing process and help interpret your results within the context of your personal and family medical history.
Book your MLH1 Genetic DNA Test today by calling our dedicated genetic testing line at +1(267) 388-9828 or schedule your appointment online. Take the first step toward personalized cancer prevention and family health management.
