MDS FISH Panel – Comprehensive Genetic Analysis for Myelodysplastic Syndromes
Understanding MDS FISH Panel Testing
The MDS FISH Panel represents a cutting-edge diagnostic approach for evaluating patients with suspected or confirmed Myelodysplastic Syndromes (MDS). This specialized genetic test utilizes fluorescence in situ hybridization (FISH) technology to detect specific chromosomal abnormalities that are critical for accurate diagnosis, prognosis assessment, and treatment planning in MDS patients.
What Does the MDS FISH Panel Detect?
This comprehensive panel specifically targets three key chromosomal regions that are frequently altered in Myelodysplastic Syndromes:
- del(5q) – Chromosome 5q Deletion: The most common chromosomal abnormality in MDS, associated with the “5q- syndrome” which typically has a more favorable prognosis
- del(7q) – Chromosome 7q Deletion: Indicates higher-risk disease with increased likelihood of progression to acute myeloid leukemia (AML)
- del(20q) – Chromosome 20q Deletion: Often associated with specific MDS subtypes and provides important prognostic information
Who Should Consider MDS FISH Panel Testing?
This test is particularly important for individuals experiencing:
- Unexplained cytopenias (low blood counts) including anemia, thrombocytopenia, or neutropenia
- Persistent fatigue, weakness, or shortness of breath
- Frequent infections or unusual bruising/bleeding
- Abnormal blood cell morphology detected in routine blood tests
- Family history of hematological disorders
- Previous abnormal bone marrow biopsy results
- Suspected transformation from MDS to acute leukemia
Clinical Benefits of MDS FISH Panel Testing
Accurate Diagnosis and Classification
The MDS FISH Panel provides critical information for distinguishing MDS from other bone marrow disorders and helps classify the specific subtype of MDS according to World Health Organization criteria.
Prognostic Assessment
Detection of specific chromosomal abnormalities allows for more accurate risk stratification using established scoring systems like the International Prognostic Scoring System (IPSS), guiding treatment intensity decisions.
Treatment Guidance
Specific genetic findings, particularly the del(5q) abnormality, can indicate responsiveness to targeted therapies such as lenalidomide, enabling personalized treatment approaches.
Disease Monitoring
The panel serves as a valuable tool for monitoring disease progression and treatment response over time, helping clinicians adjust therapeutic strategies as needed.
Understanding Your Test Results
Your MDS FISH Panel results will provide detailed information about the presence or absence of the targeted chromosomal abnormalities:
Normal Results
A normal result indicates that no significant deletions were detected in chromosomes 5q, 7q, or 20q. However, this does not completely rule out MDS, as other genetic abnormalities might be present.
Abnormal Results
The detection of specific deletions provides valuable diagnostic and prognostic information:
- del(5q) Detection: Often associated with better prognosis and potential responsiveness to specific targeted therapies
- del(7q) Detection: Typically indicates higher-risk disease requiring more aggressive treatment approaches
- del(20q) Detection: Provides additional prognostic information and helps refine disease classification
Interpretation Guidance
It’s essential to discuss your results with a qualified hematologist or oncologist who can interpret the findings in the context of your complete clinical picture, including blood counts, bone marrow morphology, and other diagnostic tests.
Test Details and Pricing
| Test Parameter | Details |
|---|---|
| Test Name | MDS FISH Panel – del(5q), del(7q), del(20q) Analysis |
| Regular Price | $350 USD |
| Discount Price | $262 USD |
| Turnaround Time | 5-7 Days |
| Sample Type | Bone Marrow / Peripheral Blood (Transport Immediately) |
| Test Components | Sodium Heparin Vacutainer (2ml) |
| Methodology | Fluorescence In Situ Hybridization (FISH) |
Pre-Test Instructions
The MDS FISH Panel requires a doctor’s prescription for testing. Please note that prescriptions are not applicable for surgery and pregnancy cases or individuals planning to travel abroad. Ensure proper sample collection and immediate transport to maintain sample integrity.
Nationwide Testing Availability
We have diagnostic branches conveniently located across the United States, serving major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art facilities ensure consistent, high-quality testing standards nationwide.
Take Control of Your Health Today
Early and accurate diagnosis of Myelodysplastic Syndromes can significantly impact treatment outcomes and quality of life. The MDS FISH Panel provides the critical genetic information needed for personalized treatment planning and optimal disease management.
Ready to schedule your MDS FISH Panel test? Our dedicated team is available to assist you with appointment scheduling, answer your questions, and guide you through the testing process.
Call or WhatsApp us today at +1(267) 388-9828 to book your comprehensive genetic analysis and take the first step toward personalized hematological care.
