KIF5A Gene SPG10 NGS Genetic DNA Test
Comprehensive Genetic Testing for Hereditary Spastic Paraplegia
The KIF5A Gene SPG10 NGS Genetic DNA Test represents a breakthrough in neurological genetic diagnostics, offering precise detection of mutations associated with hereditary spastic paraplegia type 10 (SPG10). This advanced next-generation sequencing test provides crucial insights for patients and families affected by progressive neurological conditions, enabling accurate diagnosis and informed medical decision-making.
What is the KIF5A Gene SPG10 Test?
The KIF5A gene encodes kinesin family member 5A, a motor protein essential for intracellular transport in neurons. Mutations in this gene disrupt axonal transport mechanisms, leading to the characteristic symptoms of SPG10 – a form of hereditary spastic paraplegia. Our NGS-based testing methodology examines the entire KIF5A gene with exceptional accuracy, identifying both known and novel pathogenic variants that contribute to this neurological disorder.
What Does the Test Detect?
This comprehensive genetic analysis identifies:
- Pathogenic mutations in the KIF5A gene associated with SPG10
- Missense, nonsense, and frameshift variants affecting protein function
- Autosomal dominant inheritance patterns
- Both familial and de novo mutations
- Variants affecting kinesin motor domain function
Who Should Consider This Test?
This genetic test is recommended for individuals experiencing:
- Progressive lower limb spasticity and weakness
- Difficulty walking or abnormal gait patterns
- Family history of hereditary spastic paraplegia
- Unexplained neurological symptoms in childhood or adulthood
- Muscle stiffness and hyperreflexia in the legs
- Urinary urgency or other autonomic symptoms
- Early-onset progressive neurological decline
Key Benefits of KIF5A Genetic Testing
- Accurate Diagnosis: Provides definitive identification of SPG10 causative mutations
- Family Planning: Enables informed reproductive decisions for at-risk families
- Treatment Guidance: Helps neurologists develop targeted management strategies
- Prognostic Information: Offers insights into disease progression and severity
- Genetic Counseling: Supports comprehensive understanding of inheritance patterns
- Research Contribution: Advances scientific knowledge of hereditary neurological disorders
Understanding Your Test Results
Your genetic test results will fall into one of several categories:
Positive Result
A positive result indicates the presence of a pathogenic mutation in the KIF5A gene, confirming SPG10 diagnosis. This information enables targeted symptom management and family screening.
Negative Result
A negative result suggests that KIF5A mutations are not responsible for your symptoms, guiding further diagnostic evaluation for other potential causes.
Variant of Uncertain Significance
Some genetic changes may have unknown clinical significance. Our genetic counselors provide comprehensive interpretation and follow-up recommendations.
Test Pricing and Details
| Test Feature | Details |
|---|---|
| Test Name | KIF5A Gene SPG10 NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements
Before testing, we recommend:
- Comprehensive clinical history documentation
- Genetic counseling session with our specialists
- Development of detailed family pedigree chart
- Discussion of potential implications and outcomes
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network ensures accessible genetic testing services regardless of your location.
Take Control of Your Neurological Health
Don’t let uncertainty about hereditary neurological conditions affect your quality of life. The KIF5A Gene SPG10 NGS Genetic DNA Test provides the clarity needed for proper diagnosis and management. Our team of neurological genetics specialists is ready to support you through every step of the testing process.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your test. Take the first step toward understanding your genetic health and planning for the future.
