INSR Gene Diabetes Mellitus Insulin-Resistant with Acanthosis Nigricans NGS Genetic DNA Test
Comprehensive Genetic Testing for Insulin Resistance Disorders
The INSR Gene Diabetes Mellitus Insulin-Resistant with Acanthosis Nigricans NGS Genetic DNA Test represents a breakthrough in molecular diagnostics for rare metabolic disorders. This advanced genetic test specifically targets mutations in the insulin receptor (INSR) gene, which plays a critical role in insulin signaling and glucose metabolism. When this gene malfunctions, it leads to severe insulin resistance, a condition where the body’s cells fail to respond properly to insulin, resulting in elevated blood glucose levels despite adequate insulin production.
What This Test Measures and Detects
Our state-of-the-art Next-Generation Sequencing (NGS) technology comprehensively analyzes the entire INSR gene to identify:
- Point mutations affecting insulin receptor function
- Insertions and deletions disrupting gene structure
- Missense and nonsense mutations altering protein production
- Regulatory region variants affecting gene expression
- Compound heterozygous mutations in severe cases
Who Should Consider This Genetic Test
This specialized genetic test is recommended for individuals presenting with:
- Severe insulin resistance unresponsive to conventional diabetes treatments
- Characteristic acanthosis nigricans (dark, velvety skin patches in body folds)
- Early-onset diabetes with unusual clinical presentation
- Family history of similar metabolic disorders
- Hyperandrogenism in females with insulin resistance
- Growth abnormalities and developmental delays
- Unexplained metabolic syndrome in young individuals
Clinical Benefits of Genetic Testing
Undergoing the INSR gene test provides numerous clinical advantages:
- Accurate Diagnosis: Confirms or rules out rare genetic forms of diabetes
- Personalized Treatment: Guides targeted therapeutic approaches
- Family Planning: Provides crucial information for genetic counseling
- Early Intervention: Enables proactive management strategies
- Prognostic Information: Helps predict disease progression and complications
- Research Contribution: Advances understanding of rare metabolic disorders
Understanding Your Test Results
Our comprehensive genetic analysis provides detailed insights into your INSR gene status:
Positive Result Interpretation
A positive result indicates the presence of pathogenic mutations in the INSR gene. This confirms the diagnosis of insulin-resistant diabetes with acanthosis nigricans. Our genetic counselors will provide detailed explanations about:
- Specific mutation type and its functional consequences
- Inheritance patterns and family risk assessment
- Personalized management recommendations
- Available treatment options and clinical trials
- Lifestyle modifications and monitoring requirements
Negative Result Interpretation
A negative result suggests no detectable mutations in the INSR gene. However, this doesn’t completely rule out genetic causes, as rare mutations or variants in other genes might be responsible. Further testing or clinical evaluation may be recommended based on your specific symptoms and family history.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Nationwide Testing Availability
We have comprehensive testing facilities across the United States, with branches in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures convenient access to advanced genetic testing services regardless of your location.
Pre-Test Requirements and Sample Collection
Before undergoing testing, we recommend:
- Comprehensive clinical history documentation
- Genetic counseling session to create detailed family pedigree
- Discussion of testing implications and potential outcomes
- Understanding of insurance coverage and financial considerations
Sample Types Accepted: Blood, Extracted DNA, or One Drop Blood on FTA Card
Turnaround Time: 3 to 4 Weeks
Take Control of Your Metabolic Health Today
Don’t let unexplained insulin resistance and metabolic symptoms go undiagnosed. Our advanced INSR gene testing provides the clarity needed for proper diagnosis and targeted treatment. Early genetic identification can significantly improve long-term health outcomes and quality of life.
Ready to schedule your genetic test? Contact our specialists today at +1(267) 388-9828 or book your appointment online. Our genetic counselors are available to answer your questions and guide you through the testing process.
Take the first step toward understanding your genetic metabolic profile and receive personalized care from our experienced team of genetic specialists and metabolic disorder experts.
