IL12RB1 Gene Atypical Mycobacterial Infection NGS Genetic DNA Test
Comprehensive Genetic Analysis for Immune System Disorders
The IL12RB1 Gene Atypical Mycobacterial Infection NGS Genetic DNA Test represents a breakthrough in genetic diagnostics for individuals suffering from recurrent and severe infections. This advanced test specifically targets the IL12RB1 gene, which encodes a crucial component of the interleukin-12 receptor beta-1 chain. This receptor plays a vital role in the immune system’s ability to combat intracellular pathogens, particularly atypical mycobacteria that typically cause minimal disease in immunocompetent individuals.
What Does This Test Measure?
Our state-of-the-art Next-Generation Sequencing (NGS) technology comprehensively analyzes the entire IL12RB1 gene to identify:
- Point mutations affecting protein function
- Insertions and deletions disrupting gene expression
- Copy number variations impacting receptor density
- Splice site mutations altering protein structure
- Regulatory region variants affecting gene expression
The test provides complete coverage of all coding regions, exon-intron boundaries, and known regulatory elements to ensure comprehensive mutation detection.
Who Should Consider This Genetic Test?
This specialized genetic test is particularly recommended for individuals presenting with:
- Recurrent or severe atypical mycobacterial infections despite appropriate treatment
- Unexplained disseminated mycobacterial disease in otherwise healthy individuals
- Family history of similar infection patterns across generations
- Early-onset mycobacterial infections in childhood or adolescence
- Associated clinical features including chronic skin lesions, osteomyelitis, or lymphadenitis
- Consanguineous parentage with increased genetic risk
Clinical Benefits of Genetic Testing
Undergoing the IL12RB1 genetic test provides numerous clinical advantages:
- Precise Diagnosis: Confirms genetic susceptibility to atypical mycobacterial infections
- Personalized Treatment: Guides targeted therapeutic interventions based on genetic findings
- Family Planning: Enables informed reproductive decisions and genetic counseling
- Early Intervention: Facilitates proactive management strategies for at-risk family members
- Improved Outcomes: Reduces diagnostic uncertainty and inappropriate treatments
- Comprehensive Care: Integrates dermatological, immunological, and genetic perspectives
Understanding Your Test Results
Our comprehensive genetic counseling service helps you interpret your results:
- Positive Result: Identifies pathogenic mutations confirming IL12RB1 deficiency with specific management recommendations
- Negative Result: Rules out IL12RB1 mutations, directing further diagnostic evaluation
- Variant of Uncertain Significance: Identifies genetic changes requiring additional family studies and clinical correlation
- Carrier Status: Determines inheritance patterns and reproductive risks
All results include detailed explanations and access to our genetic counseling team for comprehensive discussion and planning.
Test Pricing and Availability
| Test Description | Price (USD) |
|---|---|
| IL12RB1 Gene Atypical Mycobacterial Infection NGS Genetic DNA Test – Discount Price | $500 |
| IL12RB1 Gene Atypical Mycobacterial Infection NGS Genetic DNA Test – Regular Price | $700 |
Nationwide Testing Availability
We provide comprehensive genetic testing services across the United States with convenient locations in:
- New York City, NY
- Los Angeles, CA
- Chicago, IL
- Houston, TX
- Phoenix, AZ
- Philadelphia, PA
- San Antonio, TX
- San Diego, CA
- Dallas, TX
- San Jose, CA
Our network of certified genetic counselors and specialized laboratories ensures consistent, high-quality testing nationwide.
Sample Collection and Processing
We offer flexible sample collection options to accommodate your needs:
- Blood Sample: Standard venipuncture collection at our certified facilities
- Extracted DNA: Pre-extracted DNA samples from qualified laboratories
- FTA Card: Convenient single blood drop collection for remote testing
Turnaround time for results is typically 3-4 weeks from sample receipt, with expedited options available for urgent clinical situations.
Pre-Test Requirements
To ensure optimal testing outcomes, we recommend:
- Comprehensive clinical history documentation
- Genetic counseling session to discuss testing implications
- Family pedigree analysis to identify inheritance patterns
- Review of previous infection history and treatment responses
- Discussion of potential results and their clinical significance
Take Control of Your Genetic Health Today
Don’t let unexplained infections compromise your quality of life. Our IL12RB1 genetic test provides the answers you need for targeted treatment and comprehensive care management. With our discounted price of $500 USD and nationwide availability, advanced genetic testing has never been more accessible.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your test. Our team of genetic specialists is ready to guide you through every step of the testing process and help you understand your results for better health outcomes.