DNAJC6 Gene PARK19 Parkinson Juvenile-Onset NGS Genetic DNA Test
Understanding Juvenile-Onset Parkinson’s Disease
Juvenile-onset Parkinson’s disease represents a rare form of Parkinson’s that manifests before the age of 21, with PARK19 being specifically linked to mutations in the DNAJC6 gene. This specialized genetic test utilizes cutting-edge Next-Generation Sequencing (NGS) technology to identify pathogenic variants in the DNAJC6 gene, providing crucial diagnostic information for patients and families affected by early-onset Parkinson’s symptoms.
What This Test Measures and Detects
The DNAJC6 Gene PARK19 NGS Genetic DNA Test comprehensively analyzes the entire coding region of the DNAJC6 gene to identify:
- Pathogenic mutations associated with PARK19 Parkinson’s disease
- Single nucleotide variants (SNVs) and small insertions/deletions
- Copy number variations (CNVs) affecting the DNAJC6 gene
- Novel genetic variants with potential clinical significance
Clinical Significance of DNAJC6 Mutations
The DNAJC6 gene encodes auxilin, a protein crucial for clathrin-mediated endocytosis in neuronal cells. Mutations in this gene disrupt dopamine receptor recycling and synaptic vesicle trafficking, leading to the characteristic Parkinson’s symptoms observed in juvenile-onset cases.
Who Should Consider This Test
This genetic test is particularly recommended for individuals experiencing:
- Early-onset Parkinson’s symptoms before age 21
- Progressive movement disorders in childhood or adolescence
- Family history of juvenile Parkinson’s disease
- Unexplained tremors, rigidity, or bradykinesia in young patients
- Developmental delays accompanied by movement abnormalities
- Suspected genetic Parkinson’s syndromes
Symptoms Indicating Need for Testing
- Resting tremors in hands or limbs
- Muscle stiffness and rigidity
- Slowed movements (bradykinesia)
- Postural instability and balance problems
- Difficulty with fine motor tasks
- Speech and swallowing difficulties
Benefits of DNAJC6 Genetic Testing
Undergoing the DNAJC6 Gene PARK19 NGS Test provides numerous advantages:
- Accurate Diagnosis: Confirms or rules out genetic juvenile-onset Parkinson’s
- Early Intervention: Enables timely treatment and management strategies
- Family Planning: Provides genetic counseling information for family members
- Personalized Treatment: Guides medication selection and therapy approaches
- Prognostic Information: Helps understand disease progression patterns
- Research Contribution: Advances understanding of rare Parkinson’s forms
Understanding Your Test Results
Your DNAJC6 genetic test results will fall into one of these categories:
Positive Result
A positive result indicates the presence of a pathogenic mutation in the DNAJC6 gene, confirming the diagnosis of PARK19 juvenile-onset Parkinson’s disease. This result enables:
- Targeted treatment planning with neurologists
- Family genetic counseling and testing
- Access to specialized Parkinson’s resources
- Participation in clinical trials for rare Parkinson’s forms
Negative Result
A negative result means no pathogenic DNAJC6 mutations were detected. This helps:
- Rule out PARK19 as the cause of symptoms
- Guide further diagnostic investigations
- Explore other genetic or environmental causes
- Provide reassurance for family planning
Variant of Uncertain Significance (VUS)
Some results may identify genetic changes with unknown clinical impact. In such cases:
- Additional family studies may be recommended
- Ongoing research may clarify significance over time
- Clinical correlation with symptoms is essential
- Periodic re-evaluation may be necessary
Test Pricing Information
| Test Name | Regular Price | Discount Price |
|---|---|---|
| DNAJC6 Gene PARK19 Parkinson Juvenile-Onset NGS Genetic DNA Test | $700 USD | $500 USD |
Test Specifications
- Turnaround Time: 3 to 4 Weeks
- Sample Type: Blood, Extracted DNA, or One Drop Blood on FTA Card
- Testing Method: Next-Generation Sequencing (NGS) Technology
- Specialty: Neurology and Genetics
- Disease Category: Neurological Disorders
Pre-Test Requirements
Before scheduling your DNAJC6 genetic test, please ensure:
- Complete clinical history documentation
- Genetic counseling session to create family pedigree chart
- Discussion of testing implications with healthcare provider
- Informed consent for genetic testing
- Insurance pre-authorization if applicable
Nationwide Testing Availability
We have diagnostic centers across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified genetic counselors and neurologists ensures comprehensive care throughout your testing journey.
Take Control of Your Neurological Health
Early detection and accurate diagnosis are crucial for managing juvenile-onset Parkinson’s disease effectively. The DNAJC6 Gene PARK19 NGS Genetic DNA Test provides the clarity needed to make informed healthcare decisions and access appropriate treatments.
Ready to schedule your genetic test? Call our genetic specialists today at +1(267) 388-9828 or book your appointment online. Take the first step toward understanding your neurological health with confidence and precision.
