CASP8 Gene Autoimmune Lymphoproliferative Syndrome Type 2B NGS Genetic DNA Test
Understanding Autoimmune Lymphoproliferative Syndrome Type 2B
Autoimmune Lymphoproliferative Syndrome Type 2B (ALPS Type 2B) is a rare genetic disorder characterized by abnormal immune system function resulting from mutations in the CASP8 gene. This condition leads to impaired apoptosis (programmed cell death) of lymphocytes, causing chronic lymphadenopathy, splenomegaly, and autoimmune manifestations. The CASP8 gene plays a critical role in regulating immune cell death and maintaining immune system homeostasis.
What This Test Measures and Detects
Our advanced NGS Genetic DNA Test specifically analyzes the CASP8 gene for mutations associated with Autoimmune Lymphoproliferative Syndrome Type 2B. The test provides comprehensive coverage of:
- Complete sequencing of the CASP8 gene coding regions
- Detection of point mutations, insertions, and deletions
- Identification of pathogenic variants affecting caspase-8 function
- Analysis of genetic variations impacting immune cell apoptosis
Who Should Consider This Test
This genetic test is recommended for individuals presenting with:
- Unexplained chronic lymphadenopathy (swollen lymph nodes)
- Persistent splenomegaly (enlarged spleen)
- Autoimmune manifestations including cytopenias
- Recurrent infections and immune dysregulation
- Family history of autoimmune lymphoproliferative disorders
- Children with unexplained immune system abnormalities
- Patients with suspected genetic immune disorders
Clinical Benefits of Genetic Testing
Undergoing the CASP8 Gene Autoimmune Lymphoproliferative Syndrome Type 2B NGS Genetic DNA Test provides numerous clinical advantages:
- Accurate Diagnosis: Confirms or rules out ALPS Type 2B with high precision
- Personalized Treatment: Guides appropriate immunosuppressive therapy
- Family Planning: Provides genetic counseling information for affected families
- Early Intervention: Enables proactive management of complications
- Disease Monitoring: Helps track disease progression and treatment response
Understanding Your Test Results
Our comprehensive genetic analysis provides clear, actionable results:
- Positive Result: Indicates the presence of pathogenic CASP8 mutations, confirming ALPS Type 2B diagnosis
- Negative Result: Suggests absence of known CASP8 mutations associated with ALPS Type 2B
- Variant of Uncertain Significance: Identifies genetic changes requiring further clinical correlation
- Carrier Status: Determines inheritance patterns for family members
Test Pricing Information
| Test Description | Price (USD) |
|---|---|
| CASP8 Gene Autoimmune Lymphoproliferative Syndrome Type 2B NGS Genetic DNA Test – Discount Price | $500 |
| CASP8 Gene Autoimmune Lymphoproliferative Syndrome Type 2B NGS Genetic DNA Test – Regular Price | $700 |
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our state-of-the-art facilities ensure consistent, high-quality genetic testing services nationwide.
Schedule Your Genetic Test Today
Take the first step toward accurate diagnosis and personalized treatment. Our genetic counselors and medical specialists are ready to assist you with comprehensive testing and interpretation services. Contact us today to schedule your CASP8 Gene Autoimmune Lymphoproliferative Syndrome Type 2B NGS Genetic DNA Test.
Call or WhatsApp: +1(267) 388-9828
Our team provides complete support throughout the testing process, from sample collection to result interpretation and genetic counseling. With a turnaround time of 3-4 weeks, you’ll receive timely, accurate results to guide your healthcare decisions.
