CACNA1A Gene Familial Hemiplegic Migraine Type 1 NGS Genetic DNA Test
Understanding Familial Hemiplegic Migraine Type 1
Familial Hemiplegic Migraine Type 1 (FHM1) represents a rare and severe form of migraine disorder characterized by temporary paralysis or weakness on one side of the body during migraine attacks. This neurological condition is inherited in an autosomal dominant pattern, meaning a single copy of the mutated gene from either parent can cause the disorder. The CACNA1A gene test provides definitive genetic confirmation for individuals and families affected by this debilitating condition.
What Does the CACNA1A Gene Test Measure?
This advanced genetic test specifically analyzes the CACNA1A gene located on chromosome 19, which encodes the alpha-1A subunit of voltage-gated calcium channels in the brain. These calcium channels play a crucial role in neurotransmitter release and neuronal communication. The test detects:
- Pathogenic mutations in the CACNA1A gene associated with FHM1
- Specific nucleotide changes affecting calcium channel function
- Genetic variations that disrupt normal neuronal signaling
- Inheritance patterns within affected families
Who Should Consider This Genetic Test?
This specialized neurological genetic test is recommended for individuals experiencing:
- Recurrent migraine attacks with temporary hemiplegia (one-sided weakness)
- Family history of hemiplegic migraines or similar neurological symptoms
- Severe migraine episodes accompanied by aura symptoms lasting hours to days
- Additional neurological features such as ataxia, seizures, or consciousness alterations
- Uncertain diagnosis despite comprehensive neurological evaluation
- Planning for family and reproductive decisions
Clinical Benefits of CACNA1A Genetic Testing
Undergoing this comprehensive genetic analysis provides numerous clinical advantages:
- Definitive Diagnosis: Confirms or rules out FHM1 with high accuracy
- Personalized Treatment: Guides appropriate migraine management strategies
- Family Planning: Provides crucial information for genetic counseling and reproductive decisions
- Risk Assessment: Identifies at-risk family members for early intervention
- Prognostic Information: Helps understand potential disease progression and complications
- Therapeutic Guidance: Informs medication choices and preventive measures
Understanding Your Test Results
Your genetic test results will be carefully interpreted by our expert genetic counselors and neurologists:
- Positive Result: Indicates a pathogenic mutation in the CACNA1A gene, confirming FHM1 diagnosis
- Negative Result: Suggests absence of known FHM1-causing mutations in the CACNA1A gene
- Variant of Uncertain Significance: Identifies genetic changes with unknown clinical impact requiring further evaluation
- Comprehensive Report: Includes detailed interpretation, clinical implications, and family counseling recommendations
Test Specifications and Pricing
| Test Component | Details |
|---|---|
| Test Name | CACNA1A Gene Familial Hemiplegic Migraine Type 1 NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next Generation Sequencing (NGS) Technology |
Pre-Test Requirements
Before scheduling your CACNA1A genetic test, we recommend:
- Complete clinical history documentation of neurological symptoms
- Genetic counseling session to create detailed family pedigree chart
- Discussion of test implications, benefits, and limitations
- Informed consent process understanding potential outcomes
Nationwide Testing Availability
We provide comprehensive genetic testing services across the United States with convenient locations in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, and Philadelphia. Our state-of-the-art laboratories ensure accurate and reliable results for patients nationwide.
Take Control of Your Neurological Health
Don’t let uncertainty about your migraine condition affect your quality of life. The CACNA1A Gene Familial Hemiplegic Migraine Type 1 NGS Genetic DNA Test provides the clarity needed for proper diagnosis and management. Our team of genetic specialists and neurologists are ready to support you through every step of the testing process.
Ready to schedule your genetic test? Contact our genetic counseling team today at +1(267) 388-9828 or book your appointment online. Take the first step toward understanding your neurological health and making informed decisions about your care.
