BCR-ABL1 Quantification by Droplet Digital PCR
Understanding BCR-ABL1 Quantification Testing
BCR-ABL1 Quantification by Droplet Digital PCR represents a breakthrough in molecular diagnostics for Chronic Myeloid Leukemia (CML) management. This highly sophisticated test provides unprecedented precision in monitoring treatment response and detecting minimal residual disease, offering patients and healthcare providers critical insights for personalized cancer care.
What Does This Test Measure?
The BCR-ABL1 Quantification test specifically detects and quantifies the BCR-ABL1 fusion gene transcript, which results from the Philadelphia chromosome translocation. This genetic abnormality is the hallmark of Chronic Myeloid Leukemia and serves as the primary therapeutic target for tyrosine kinase inhibitors.
- Precise measurement of BCR-ABL1 transcript levels
- Detection of minimal residual disease
- Monitoring treatment response to targeted therapies
- Assessment of molecular remission status
Who Should Consider BCR-ABL1 Testing?
This advanced diagnostic test is essential for several patient populations and clinical scenarios:
Primary Indications
- Patients diagnosed with Chronic Myeloid Leukemia (CML)
- Individuals undergoing tyrosine kinase inhibitor therapy
- Patients requiring treatment response monitoring
- Those experiencing potential treatment resistance
- Patients in molecular remission requiring ongoing surveillance
Clinical Symptoms and Scenarios
Consider this test if you or your patient presents with:
- Unexplained fatigue and weakness
- Enlarged spleen or abdominal discomfort
- Night sweats and unexplained weight loss
- Abnormal blood counts suggesting leukemia
- Need for precise treatment monitoring
Benefits of BCR-ABL1 Quantification Testing
Enhanced Treatment Precision
Our Droplet Digital PCR technology offers superior sensitivity and accuracy compared to traditional quantitative PCR methods. This advanced approach enables:
- Early detection of treatment resistance
- Precise monitoring of molecular response
- Improved guidance for therapy adjustments
- Better prediction of long-term outcomes
Clinical Advantages
- Rapid turnaround time of 2-3 days
- Minimal sample requirement (peripheral blood)
- High sensitivity for detecting low-level disease
- Comprehensive reporting with clear clinical interpretation
Understanding Your Test Results
Interpreting BCR-ABL1 Levels
Your test results will provide crucial information about your treatment response and disease status:
- Major Molecular Response (MMR): BCR-ABL1 levels ≤0.1% indicate excellent treatment response
- Deep Molecular Response (DMR): Levels ≤0.01% suggest potential for treatment-free remission
- Treatment Failure: Rising BCR-ABL1 levels may indicate developing resistance
- Optimal Response: Consistent decline in transcript levels confirms effective therapy
Clinical Implications
Your healthcare provider will use these results to:
- Assess current treatment effectiveness
- Determine if therapy adjustments are needed
- Evaluate eligibility for treatment discontinuation
- Monitor for early signs of disease progression
Test Pricing and Availability
| Test Name | Regular Price | Discount Price |
|---|---|---|
| BCR-ABL1 Quantification by Droplet Digital PCR | $300 USD | $226 USD |
Test Specifications
- Turnaround Time: 2-3 days
- Sample Type: Peripheral Blood (Streck Tube)
- Methodology: Droplet Digital PCR
- Specialty: Oncology Genetics
Nationwide Testing Availability
GGC DNA provides comprehensive BCR-ABL1 testing services across the United States. We have established testing facilities in all major metropolitan areas including:
- New York City and surrounding areas
- Los Angeles and Southern California
- Chicago and Midwest regions
- Houston and Texas locations
- Phoenix and Southwest territories
- And all other major cities nationwide
Pre-Test Requirements
BCR-ABL1 Quantification by Droplet Digital PCR requires a doctor’s prescription for most cases. Prescription requirements do not apply for surgical planning, pregnancy-related testing, or international travel documentation purposes.
Take Control of Your Leukemia Management
Don’t leave your treatment monitoring to chance. Our advanced BCR-ABL1 Quantification testing provides the precision and reliability you need for optimal leukemia management. With rapid results and comprehensive reporting, you’ll have the information necessary to make informed decisions about your care.
Ready to schedule your test? Contact us today at +1(267) 388-9828 or book your appointment online. Our genetic specialists are available to answer your questions and guide you through the testing process.
Take the next step in personalized cancer care with GGC DNA’s state-of-the-art BCR-ABL1 Quantification testing. Your journey to precise leukemia management starts here.
