ATP8B1 Gene Cholestasis Intrahepatic of Pregnancy Type 1 NGS Genetic DNA Test
Understanding Intrahepatic Cholestasis of Pregnancy
Intrahepatic cholestasis of pregnancy (ICP) is a serious liver condition that affects pregnant women, characterized by impaired bile flow and accumulation of bile acids in the bloodstream. The ATP8B1 Gene Cholestasis Intrahepatic of Pregnancy Type 1 NGS Genetic DNA Test represents a breakthrough in prenatal genetic screening, specifically targeting mutations in the ATP8B1 gene that are responsible for this potentially dangerous condition.
What is ATP8B1 Gene and Its Role?
The ATP8B1 gene encodes a protein called FIC1, which plays a crucial role in maintaining bile acid homeostasis in liver cells. When mutations occur in this gene, it disrupts the normal flow of bile from liver cells to the bile ducts, leading to cholestasis during pregnancy. This condition typically manifests in the third trimester and can pose significant risks to both mother and developing baby.
What Does This Test Measure?
Our advanced NGS Genetic DNA Test specifically analyzes:
- Complete sequencing of the ATP8B1 gene to identify pathogenic variants
- Detection of known mutations associated with progressive familial intrahepatic cholestasis type 1
- Assessment of genetic predisposition to pregnancy-related liver complications
- Identification of autosomal recessive inheritance patterns
Who Should Consider This Test?
Clinical Indications and Symptoms
This genetic test is particularly recommended for women experiencing:
- Unexplained severe itching (pruritus) during pregnancy, especially on palms and soles
- Elevated liver enzymes or abnormal liver function tests during pregnancy
- Family history of intrahepatic cholestasis or liver disorders
- Previous pregnancies complicated by cholestasis or liver issues
- Dark urine, pale stools, or jaundice during pregnancy
- Unexplained fatigue, nausea, or abdominal discomfort in pregnancy
Benefits of Genetic Testing
Undergoing the ATP8B1 genetic test provides numerous advantages:
- Early Risk Assessment: Identify genetic predisposition before symptoms appear
- Personalized Management: Enable targeted monitoring and treatment strategies
- Family Planning Guidance: Understand inheritance risks for future pregnancies
- Improved Pregnancy Outcomes: Early intervention can reduce complications
- Comprehensive Genetic Counseling: Professional interpretation of results and implications
Understanding Your Test Results
Interpreting Genetic Findings
Our comprehensive results include:
- Positive Result: Indicates presence of ATP8B1 gene mutations associated with increased risk of intrahepatic cholestasis. Requires consultation with maternal-fetal medicine specialist and genetic counselor.
- Negative Result: No detected mutations in the ATP8B1 gene, significantly reducing genetic risk for this specific condition.
- Variant of Uncertain Significance: Rare genetic changes with unclear clinical implications, requiring ongoing monitoring and possible family studies.
Clinical Follow-up Recommendations
Based on your results, our genetic counselors will provide:
- Detailed explanation of inheritance patterns and family risk assessment
- Recommendations for pregnancy management and monitoring
- Guidance on potential treatments including ursodeoxycholic acid therapy
- Information about timing of delivery and neonatal care considerations
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | ATP8B1 Gene Cholestasis Intrahepatic of Pregnancy Type 1 NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
| Specialty | General Physician & Genetics |
Pre-Test Requirements
Before scheduling your test, we recommend:
- Complete clinical history documentation
- Genetic counseling session to create family pedigree chart
- Discussion of potential implications and limitations of testing
- Informed consent process for genetic testing
Nationwide Availability
We have convenient testing locations across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified genetic counselors and healthcare professionals ensures you receive comprehensive care regardless of your location.
Take Control of Your Pregnancy Health
Don’t let uncertainty about genetic risks affect your pregnancy journey. Our ATP8B1 genetic test provides the clarity and information needed to make informed decisions about your health and your baby’s wellbeing. With our discounted price of $500 USD and comprehensive genetic counseling support, you can approach your pregnancy with confidence and peace of mind.
Ready to schedule your test? Call or WhatsApp us today at +1(267) 388-9828 to book your appointment and take the first step toward understanding your genetic health during pregnancy.
