ABCB4 Gene Cholestasis Intrahepatic of Pregnancy Type 3 NGS Genetic DNA Test
Comprehensive Genetic Testing for Pregnancy-Related Liver Disorders
The ABCB4 Gene Cholestasis Intrahepatic of Pregnancy Type 3 NGS Genetic DNA Test represents a significant advancement in prenatal and maternal healthcare diagnostics. This specialized genetic test focuses on identifying mutations in the ABCB4 gene, which encodes the multidrug resistance protein 3 (MDR3) – a critical transporter protein responsible for phospholipid secretion into bile. When this gene malfunctions, it can lead to intrahepatic cholestasis of pregnancy type 3, a serious liver condition that affects expectant mothers and poses risks to both maternal and fetal health.
What This Test Measures and Detects
Our advanced NGS Genetic DNA Test provides comprehensive analysis of the ABCB4 gene to identify:
- Pathogenic mutations in the ABCB4 gene sequence
- Single nucleotide variants (SNVs) affecting bile transport function
- Insertions and deletions that disrupt normal protein production
- Splice site mutations impacting gene expression
- Copy number variations affecting gene dosage
The test utilizes state-of-the-art Next-Generation Sequencing technology, offering unparalleled accuracy in detecting even the most subtle genetic variations that could contribute to intrahepatic cholestasis during pregnancy.
Who Should Consider This Genetic Test
This test is particularly recommended for women experiencing or with a history of:
- Unexplained itching (pruritus) during pregnancy, especially in the third trimester
- Elevated liver enzymes without clear cause during pregnancy
- Previous episodes of intrahepatic cholestasis of pregnancy
- Family history of pregnancy-related liver disorders
- Unexplained stillbirth or preterm delivery in previous pregnancies
- Abnormal bile acid levels during pregnancy monitoring
- Personal history of gallstones or other biliary tract issues
Clinical Benefits of Genetic Testing
Undergoing the ABCB4 Gene Cholestasis Intrahepatic of Pregnancy Type 3 NGS Genetic DNA Test offers numerous advantages:
- Accurate Diagnosis: Confirms or rules out genetic causes of pregnancy-related liver issues
- Personalized Treatment: Enables targeted therapeutic approaches based on genetic findings
- Risk Assessment: Helps evaluate recurrence risks for future pregnancies
- Family Planning: Provides valuable information for genetic counseling and family planning decisions
- Early Intervention: Facilitates proactive management strategies to protect maternal and fetal health
- Peace of Mind: Reduces uncertainty and anxiety about unexplained pregnancy complications
Understanding Your Test Results
Our comprehensive genetic counseling support helps you interpret your results effectively:
- Positive Result: Indicates the presence of ABCB4 gene mutations associated with intrahepatic cholestasis of pregnancy type 3. This information guides specialized prenatal care and monitoring protocols.
- Negative Result: Suggests that ABCB4 gene mutations are not the cause of your symptoms, directing further investigation toward other potential causes.
- Variant of Uncertain Significance (VUS): Some genetic changes may require additional family studies or research to determine clinical significance.
All results are accompanied by detailed explanations from our certified genetic counselors, ensuring you fully understand the implications for your health and future pregnancies.
Test Information and Pricing
| Test Component | Details |
|---|---|
| Test Name | ABCB4 Gene Cholestasis Intrahepatic of Pregnancy Type 3 NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
| Specialty | General Physician, Genetics |
| Disease Category | Metabolic Disorders |
Pre-Test Requirements
To ensure optimal testing accuracy and comprehensive care:
- Complete clinical history documentation of the patient undergoing testing
- Genetic counseling session to create detailed family pedigree chart
- Documentation of family members affected with cholestasis intrahepatic of pregnancy type 3
- Review of previous pregnancy complications and liver function tests
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified genetic testing facilities ensures consistent quality and reliable results nationwide.
Take Control of Your Reproductive Health
Don’t let uncertainty about pregnancy-related liver complications affect your family planning decisions. Our ABCB4 Gene Cholestasis Intrahepatic of Pregnancy Type 3 NGS Genetic DNA Test provides the clarity and confidence you need for informed healthcare decisions.
Ready to schedule your genetic test? Contact our genetic specialists today at +1(267) 388-9828 or book your appointment online. Take the first step toward understanding your genetic risk factors and ensuring healthier pregnancy outcomes.
