Systemic Sclerosis Profile IgG Test
Comprehensive Autoimmune Disorder Detection
The Systemic Sclerosis Profile IgG Test represents a cutting-edge diagnostic approach for identifying and characterizing systemic sclerosis, commonly known as scleroderma. This sophisticated immunoblot-based analysis provides rheumatologists with essential data to accurately diagnose and manage this complex autoimmune condition affecting connective tissues throughout the body.
What This Advanced Test Measures
Our comprehensive IgG profile detects 13 critical autoantibodies associated with systemic sclerosis:
- Scl-70 (Topoisomerase I) – Strongly associated with diffuse systemic sclerosis
- CENP A & CENP B – Centromere proteins indicating limited cutaneous systemic sclerosis
- RNA Polymerase III (RP11 & RP155) – Markers for rapid disease progression
- Fibrillarin, NOR90, Th/To – Nuclear and nucleolar antibodies
- PM-Scl 100 & PM-Scl 75 – Polymyositis-scleroderma overlap markers
- Ku, PDGFR, Ro-52 – Additional autoimmune indicators
Who Should Consider This Important Test
This diagnostic profile is particularly valuable for individuals experiencing:
- Progressive skin thickening and tightening
- Raynaud’s phenomenon with digital ulcers
- Gastrointestinal complications including reflux and dysphagia
- Pulmonary symptoms such as shortness of breath
- Joint pain and musculoskeletal discomfort
- Calcinosis cutis or telangiectasias
- Family history of autoimmune disorders
Significant Benefits of Early Detection
Undergoing the Systemic Sclerosis Profile IgG Test provides multiple advantages:
- Early Intervention – Detect autoimmune activity before irreversible tissue damage occurs
- Disease Subtyping – Differentiate between limited and diffuse systemic sclerosis variants
- Prognostic Insights – Predict potential organ involvement and disease progression
- Treatment Guidance – Inform targeted therapeutic strategies based on antibody profiles
- Monitoring Capability – Track disease activity and treatment response over time
Understanding Your Test Results
Your results will provide detailed information about specific autoantibody patterns:
- Positive Scl-70 suggests diffuse systemic sclerosis with higher risk of pulmonary fibrosis
- Centromere antibodies typically indicate limited cutaneous disease with better prognosis
- RNA Polymerase III positivity may correlate with rapid skin thickening and renal crisis risk
- Multiple antibody patterns help identify overlap syndromes and complex autoimmune presentations
Our rheumatology specialists will provide comprehensive interpretation and personalized recommendations based on your specific antibody profile.
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Systemic Sclerosis Profile IgG Test | $412 USD | $550 USD |
Nationwide Testing Accessibility
We maintain comprehensive testing facilities across the United States, with convenient locations in:
- New York City and surrounding metropolitan areas
- Los Angeles and Southern California regions
- Chicago and Illinois healthcare networks
- Houston, Dallas, and Texas medical centers
- Phoenix, Arizona and Southwest territories
- All other major metropolitan areas nationwide
Take Control of Your Health Today
Early detection of systemic sclerosis can significantly impact disease management and quality of life. Our state-of-the-art immunopathology laboratory provides accurate, reliable results with same-day turnaround when samples are submitted by 11 am Monday through Saturday.
Ready to schedule your Systemic Sclerosis Profile IgG Test? Contact our dedicated healthcare team at +1(267) 388-9828 to book your appointment or discuss testing options. Our specialists are available to answer your questions and guide you through the testing process.
Note: No special preparation required. Sample requirement: 2 mL (1 mL minimum) serum from 1 SST tube, shipped refrigerated or frozen. Report available same day by 6 pm when sample received by 11 am.
